Optimization of curcumin loaded niosomes for drug delivery applications

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorEsmaeili Rad, Monireh
dc.contributor.authorEgil, Abdurrahim Can
dc.contributor.authorOzaydin Ince, Gozde
dc.contributor.authorYuce, Meral
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2022-10-31T07:15:48Z
dc.date.available2022-10-31T07:15:48Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractControlled drug delivery is an important and challenging issue in pharmacology. The aim is to improve efficacy and reduce the side effects of drugs. Nanotechnology suggests applying various nanoparticles as carriers to overcome drug delivery limitations. The current study introduces an optimum formulation of niosomes to carry and deliver curcumin (CUR) as a hydrophobic drug to cancerous cells. In spite of numerous pharmacological properties of this natural polyphenolic compound, including anti-microbial, antioxidant, and anti-inflammatory effects, it suffers from poor stability and solubility. This work studies the optimum formulation for CUR-loaded niosome and investigates its stability based on hydrodynamic size and zeta-potential measurements. The optimum blank noisome, formulated according to a three-level Box–Behnken design, was used to load CUR as an anticancer drug. The fabricated niosomes (blank/loaded) were characterized by dynamic light scattering, Fourier transforms infrared spectroscopy and scanning electron microscopy. Prepared particles showed stability at 4 °C for up to two months. In addition, particles were durable against temperature changes from 5° to 40°C. Drug-loaded niosomes reached 99.8% drug entrapment efficiency and up to 68.33% loading capacity. Sustained-release behaviour was observed in CUR-loaded niosomes up to 25.49 ± 0.70% of CUR during 336 h. Based on cytotoxicity studies, blank niosome showed no significant toxicity effect on cells at high concentrations and after 72 h, confirming cytocompatibility of the particles. CUR-loaded niosomes had dose-dependent toxicity against cancerous cells. The concentration of 200 µg/ml of the drug-loaded carrier, containing 66.75 µg CUR, showed an IC50 effect after 48 h of exposure to cellsen_US
dc.identifier.citationEsmaeili Rad, M., Egil, A. C., Ozaydin Ince, G., Yuce, M., & Zarrabi, A. (2022). Optimization of curcumin loaded niosomes for drug delivery applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 654 doi:10.1016/j.colsurfa.2022.129921en_US
dc.identifier.doi10.1016/j.colsurfa.2022.129921en_US
dc.identifier.scopus2-s2.0-85137632906en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2022.129921
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3209
dc.identifier.volume654en_US
dc.identifier.wosWOS:000859970900007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofColloids and Surfaces A: Physicochemical and Engineering Aspectsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectCurcuminen_US
dc.subjectNiosomeen_US
dc.subjectOptimizationen_US
dc.subjectSustained Releaseen_US
dc.titleOptimization of curcumin loaded niosomes for drug delivery applicationsen_US
dc.typeArticleen_US

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