Delivering active molecules to the eye; the concept of electrospinning as potent tool for drug delivery systems

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dc.authoridokur, mehmet evren/0000-0001-7706-6452
dc.authoridÖZCAN BÜLBÜL, Ece/0000-0001-7112-923X
dc.authoridÜstündağ Okur, Neslihan/0000-0002-3210-3747
dc.authoridSiafaka, Panoraia I./0000-0001-7256-3230
dc.authoridMiliotou, Androulla/0000-0002-9111-8615
dc.authorwosidokur, mehmet evren/AAI-1962-2019
dc.authorwosidÖZCAN BÜLBÜL, Ece/ACE-7724-2022
dc.authorwosidÜstündağ Okur, Neslihan/AAI-1863-2019
dc.contributor.authorSiafaka, Panoraia I.
dc.contributor.authorBulbul, Ece Ozcan
dc.contributor.authorMiliotou, Androulla N.
dc.contributor.authorKarantas, Ioannis D.
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorOkur, Neslihan Ustundag
dc.date.accessioned2024-05-19T14:45:57Z
dc.date.available2024-05-19T14:45:57Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractOcular drug delivery is a challenging but fascinating topical route of administration. Although the eye is easily accessible to common drug formulations such as drops, its complex structure presents main obstacles to successfully deliver drugs. Low ocular bioavailability due to pre-corneal fluid and gravity drainage limits the efficacy of the products. Therefore, researchers have proposed various drug delivery systems synthesized by biomaterials, mostly polymers, which can deliver active ingredients to the ocular surface and remain for longer period. Such systems as electrospun fibrous structures resembling the extracellular matrix can embed various therapeutic molecules aiming to target eye diseases. The electrospun matrices, which can be used as inserts or implants, offer biocompatibility, biodegradability, and good mechanical properties. At the same time, they can be molded into different shapes and textures, significant features for ocular delivery. Over the last decades, the electrospinning process has offered many advancements in tissue engineering and drug delivery fields; however, the clinical translation of the electrospun fibrous matrices is still in the embryonic stages. This review article focuses on the recent therapeutic applications of ocular fibrous systems as potent drug delivery tools. In addition, authors have categorized the electrospun matrices according to the target eye disease, such as glaucoma, ocular infections, and other eye diseases.en_US
dc.identifier.doi10.1016/j.jddst.2023.104565
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85159572278en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.jddst.2023.104565
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5400
dc.identifier.volume84en_US
dc.identifier.wosWOS:001009362500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectNanofibersen_US
dc.subjectOcularen_US
dc.subjectGlaucomaen_US
dc.subjectEye Infectionsen_US
dc.subjectPolymersen_US
dc.subjectElectrospinningen_US
dc.titleDelivering active molecules to the eye; the concept of electrospinning as potent tool for drug delivery systemsen_US
dc.typeReview Articleen_US

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