Alcohol Withdrawal at Different Points in Time Distinctly Affects Wistar Rats’ Spatial Reference Memory

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dc.contributor.authorDursun, I.
dc.contributor.authorElibol, B.
dc.contributor.authorHaciosmanoglu, E.
dc.contributor.authorJakubowska-Dogru, E.
dc.date.accessioned2024-05-19T14:33:17Z
dc.date.available2024-05-19T14:33:17Z
dc.date.issued2022
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectives: The consumption of alcohol by adults may lead to severe neurodegeneration and significant behavioral problems. An increase in the harmful effects of alcohol becomes aggravated after the development of alcohol dependence. Furthermore, the serious damage from chronic alcohol intake on the hippocampus has gained attention due to its role on learning and memory. Therefore, the study aimed to examine the retention of spatial reference memory during different points in time regarding alcohol withdrawal in Wistar rats. Materials and Methods: The study has therefore administered alcohol to rats at gradually increasing doses from 4.5 to 12 g/kg/day in a binge-like manner using the intragastric intubation technique for six days followed by 24, 48, or 96 hours of alcohol withdrawal. To evaluate the effects of alcohol withdrawal, the alcohol-exposed rats have been tested regarding their spatial reference memory. Results: An adverse effect from alcohol withdrawal on memory retention was observed in the 24-hour alcohol withdrawal group. This effect decreased at 48 hours of withdrawal, but reappeared at 96 hours. Conclusion: The study’s results suggest that alcohol withdrawal itself, even after a relatively short period of alcohol intake, may also adversely affect memory. Therefore, withdrawal therapy from alcohol should be performed in a controlled manner to protect the brain from extended alcohol withdrawal-induced spatial memory impairments. © 2022, Istanbul University Press. All rights reserved.en_US
dc.identifier.doi10.26650/experimed.1193314
dc.identifier.endpage224en_US
dc.identifier.issn2667-5846
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85173932632en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage219en_US
dc.identifier.trdizinid1167567en_US
dc.identifier.urihttps://doi.org/10.26650/experimed.1193314
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1167567
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4176
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherIstanbul University Pressen_US
dc.relation.ispartofExperimeden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAlcohol Withdrawalen_US
dc.subjectİntragastric İntubationen_US
dc.subjectSpatial Reference Memoryen_US
dc.subjectWistar Raten_US
dc.titleAlcohol Withdrawal at Different Points in Time Distinctly Affects Wistar Rats’ Spatial Reference Memoryen_US
dc.typeArticleen_US

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