Effects of Melatonin and Memantine Administration on The Learning and Memory Performances of Hypoxic Juvenile Rat Pups

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dc.authoridSiğnem Eyüboğlu / 0000-0002-0253-2217en_US
dc.authorscopusidSiğnem Eyuboğlu / 57210738678
dc.authorwosidSiğnem Eyuboğlu / AAW-1273-2020
dc.contributor.authorElibol, Birsen
dc.contributor.authorŞahbaz, Çiğdem
dc.contributor.authorEyüboğlu, Siğnem
dc.contributor.authorÇevreli, Burcu
dc.contributor.authorKılıç, Ulkan
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2021-04-26T09:52:49Z
dc.date.available2021-04-26T09:52:49Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Herein, we aimed to investigate the long-term effects of neonatal hypoxia and the potential protective role of melatonin and memantine on the learning and memory. Methods: Seven-day-old rat underwent right carotid ligation, followed by hypoxia. Rat received Melatonin (MLT) (4 mg/kg), Memantine (MEM) (20 mg/kg), and MLT+MEM combination after hypoxia. We tested these rats for anxiety by elevated O-maze and for spatial learning and memory by Morris water maze (MWM) at postnatal day 45. Results: Hypoxia increased the level of anxiety compared to the control group (p=0.05) while treatment of MLT, MEM, and MLT+MEM ameliorated this effect. In addition, hypoxia produced significant decrease in spatial learning of the rats on the fourth day of training (P=0.05) and the percent time spent in the platform quadrant and the entrance frequencies to the platform quadrant compared to the control group (P=0.049 and P=0.023). Treatment of MLT, MEM, and MLT+MEM after hypoxia improved the performance of the rats at the third (P=0.686, P=0.876, P=0.977, respectively) and fourth day (P=0.738, P=0.553, P=0.789, respectively) of MWM training. The decrease in the percent time spent was ameliorated by the treatment of MLT (P=0.239), MEM (P=0.289), and MLT+MEM (P=0.567) compared to the control group. In addition, MLT treatment significantly increased the entrance frequency to the platform quadrant compared to the hypoxia group (P=0.020). Conclusion: Our data suggested that the MLT was more effective in the release of memory deficits from hypoxia-related damage. MLT might have a therapeutic value in improving hypoxic damage in the developing brain.en_US
dc.identifier.citationElibol, B., Sahbaz, C., Eyuboglu, S., Cevreli, B., Kilic, U., & Kilic, E. (2020). Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. Psychiatry and Behavioral Sciences, 10(3), 125-133.en_US
dc.identifier.doi10.5455/PBS.20200604064021en_US
dc.identifier.endpage133en_US
dc.identifier.issue3en_US
dc.identifier.startpage125en_US
dc.identifier.trdizinid428599en_US
dc.identifier.urihttps://www.doi.org/10.5455/PBS.20200604064021
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1708
dc.identifier.volume10en_US
dc.identifier.wosWOS:000640976900004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorEyüboğlu, Siğnem
dc.language.isoenen_US
dc.publisherYERKURE TANITIM & YAYINCILIK HIZMETLERI A Sen_US
dc.relation.ispartofPSYCHIATRY AND BEHAVIORAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeonatal Hypoxiaen_US
dc.subjectLearning and Memoryen_US
dc.subjectMelatoninen_US
dc.subjectMemantineen_US
dc.subjectMorris Water Mazeen_US
dc.titleEffects of Melatonin and Memantine Administration on The Learning and Memory Performances of Hypoxic Juvenile Rat Pupsen_US
dc.typeArticleen_US

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