1,3-dipolar cycloaddition reactions of the compound obtaining from cyclopentadiene-PTAD and biological activities of adducts formed selectively

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dc.authoridParham Taslimi / 0000-0002-3171-0633en_US
dc.authorscopusidParham Taslimi / 56658628800
dc.authorwosidParham Taslimi / AAL-2788-2020
dc.contributor.authorYavari, Mirali Akbar
dc.contributor.authorTaslimi, Parham
dc.contributor.authorBayrak, Çetin
dc.contributor.authorTaşkın-Tok, Tuğba
dc.contributor.authorMenzek, Abdullah
dc.date.accessioned2022-01-10T07:05:39Z
dc.date.available2022-01-10T07:05:39Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAfter known adduct (4) was synthesized by cycloaddition reaction of cyclopentadiene with 4-phenyl-1,2,4-triazoline-3,5-dione, seven new isoxazoline derivatives were synthesized from reactions of 4 with corresponding oximes prepared from benzaldehyde derivatives in the existence of the aqueous NaOCl in CH2Cl2 at 0 degrees C-RT via nitrile oxides. Four new pyrazoline derivatives were also synthesized from reactions of 4 with corresponding prepared reagents via nitrile imines. Selectively, each of all isoxazole and pyrazoline derivatives was synthesized by 1,3-dipolar cycloaddition reactions of compound 4 with the corresponding reagents. Based on the results of their biological activity analyses, K-i values for acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glucosidase (alpha-Gly) enzymes were obtained in this range 32.15 +/- 5.73-107.44 +/- 19.52 22.57 +/- 4.30-186.07 +/- 23.51, and 69.08 +/- 8.54-528.07 +/- 38.46 nM, respectively. Besides that, these compounds were subjected to molecular docking to describe the interaction against AChE, BChE, and alpha-Gly enzymes in which important interactions were visualized and evaluated with residues of the binding region in each target enzyme.en_US
dc.identifier.citationYavari, M. A., Taslimi, P., Bayrak, C., Taskin‐Tok, T., & Menzek, A. (2021). 1, 3‐Dipolar cycloaddition reactions of the compound obtaining from cyclopentadiene‐PTAD and biological activities of adducts formed selectively. Journal of Heterocyclic Chemistry.en_US
dc.identifier.doi10.1002/jhet.4426en_US
dc.identifier.isbn1943-5193
dc.identifier.issn0022-152Xen_US
dc.identifier.scopus2-s2.0-85122015754en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1002/jhet.4426
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2385
dc.identifier.wosWOS:000734792400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTaslimi, Parham
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJOURNAL OF HETEROCYCLIC CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-Glucosidase Inhibitorsen_US
dc.subjectCarbonic-Anhydraseen_US
dc.subjectCrystal-Structureen_US
dc.subjectIsoxazole Derivativesen_US
dc.subjectSwiss-Modelen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectAntioxidanten_US
dc.title1,3-dipolar cycloaddition reactions of the compound obtaining from cyclopentadiene-PTAD and biological activities of adducts formed selectivelyen_US
dc.typeArticleen_US

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