From corrosion behavior to radiation response: A comprehensive biocompatibility assessment of a CoCrMo medium entropy alloy for utility in orthopedic and dental implants

Basit Öğe Kaydı
dc.authoridHaluk Çabuk / 0000-0002-1413-2149en_US
dc.authoridTaylan Bükülmez / 0000-0001-5996-2704
dc.authorscopusidHaluk Çabuk / 56400866300
dc.authorscopusidTaylan Bükülmez / 57194395788
dc.authorwosidHaluk Çabuk / HDE-9881-2022
dc.authorwosidTaylan Bükülmez / CKE-8804-2022
dc.contributor.authorGürel, Şeyma
dc.contributor.authorNazarahari, Alireza
dc.contributor.authorCanadinç, Demircan
dc.contributor.authorGerstein, Gregory
dc.contributor.authorMaier, Harald Jacob
dc.contributor.authorÇabuk, Haluk
dc.contributor.authorBükülmez, Taylan
dc.contributor.authorCananoğlu, Mert
dc.contributor.authorYağcı, M. Barış
dc.contributor.authorToker, S. Mine
dc.contributor.authorGüneş, Şerafettin
dc.contributor.authorSoykan, Merve Nur
dc.date.accessioned2022-09-16T12:38:11Z
dc.date.available2022-09-16T12:38:11Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThis paper presents a thorough biocompatibility evaluation of a CoCrMo medium entropy alloy to assess its potential to be utilized in orthopedic and dental implants. For this purpose, a wide range of systematic exper-iments were carried out, including static immersion, cell culture and radiation experiments. In particular, chemical biocompatibility and ion release behavior of the CoCrMo alloy were studied by carrying out static immersion experiments in artificial saliva (AS), simulated body fluid (SBF) and fetal bovine serum (FBS). Detailed analysis of the surfaces of the tested samples demonstrated that both passive oxide layer and hy-droxyapatite formation occur on the CoCrMo sample surfaces immersed in AS, SBF and FBS for 28 days. The response of living cells to the CoCrMo alloy was tested utilizing cell culture experiments, and the evidence of Saos-2 cell viability and proliferation supported the static biocompatibility experiment results, indicating the potential of the CoCrMo alloy to be utilized as an orthopedic implant material. Finally, the effect of a CoCrMo implant on the actual radiation dose induced upon malignant tissue in the vicinity of the implant during a radiotherapy was evaluated by applying medical grade radiation to water phantoms circumventing CoCrMo samples. The results showed that the radiation accumulation in the tissue within the immediate vicinity of a CoCrMo implant would be a minimum, eliminating some of the undesired side effects. Overall, the results of the three different types of experiments reported in this paper have clearly demonstrated that the CoCrMo medium entropy alloy investigated in this study has significant potential to be utilized as a safe implant material in dental and orthopedic implants.en_US
dc.identifier.citationGurel, S., Nazarahari, A., Canadinc, D., Gerstein, G., Maier, H. J., Cabuk, H., Bukulmez, T., Cananoglu, M., Yagci, M. B., Toker, S. M., Gunes, S., Soykan, M. N. (2022). From corrosion behavior to radiation response: A comprehensive biocompatibility assessment of a CoCrMo medium entropy alloy for utility in orthopedic and dental implants. Intermetallics, 149.en_US
dc.identifier.doi10.1016/j.intermet.2022.107680en_US
dc.identifier.issn0966-9795en_US
dc.identifier.scopus2-s2.0-85135692388en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.intermet.2022.107680
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3149
dc.identifier.volume149en_US
dc.identifier.wosWOS:000849678200002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇabuk, Haluk
dc.institutionauthorBükülmez, Taylan
dc.language.isoenen_US
dc.publisherELSEVIER SCIen_US
dc.relation.ispartofINTERMETALLICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoCrMoen_US
dc.subjectCorrosionen_US
dc.subjectIrradiationen_US
dc.subjectBiocompatibilityen_US
dc.subjectOrthopedic Implanten_US
dc.subjectDental Implanten_US
dc.titleFrom corrosion behavior to radiation response: A comprehensive biocompatibility assessment of a CoCrMo medium entropy alloy for utility in orthopedic and dental implantsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
1-s2.0-S0966979522002217-main.pdf
Boyut:
7.27 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu