Enhancement of folliculogenesis by fresh onion juice in a rat model

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dc.authoridZiya Kalem / 0000-0002-5435-2074
dc.authorscopusidZiya Kalem / 57074016900en_US
dc.authorwosidZiya Kalem / AGY-3908-2022en_US
dc.contributor.authorYılmaz, Nafiye
dc.contributor.authorYorgancı, Ayçağ
dc.contributor.authorİnal, Hasan Ali
dc.contributor.authorSeven, Banu Yüksel
dc.contributor.authorTimur, Hakan
dc.contributor.authorKalem, Ziya
dc.date.accessioned2021-10-25T11:41:26Z
dc.date.available2021-10-25T11:41:26Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: To evaluate the effects of fresh onion juice on female infertility. Background: Onion contains several antioxidants and has been used for the subfertile woman to achieve pregnancy by herbalists. Objective: This study was carried out to investigate the effects of fresh onion juice on ovarian folliculogenesis and implantation in rats. Methods: Female albino rats were divided into two groups: 5-day (one estrus cycle) and 10-day treatment (two estrus cycles) groups. The animals in the two groups were then divided into subgroups of the control group, 1 cc onion juice and 2 cc onion juice, each containing seven rats. At the end of the 5th and 10th days, ovarian volume and weight were measured, and the primordial, antral, and atretic follicles, and corpus lutea were counted. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) were evaluated both in the ovaries and in the endometrium immunohistochemically. Results: In the 5-day treatment group, ovarian weight and the antral follicle count were significantly higher in the 2 cc onion juice subgroup than the control group (p<0.05). In the 10-day treatment group, the antral follicle count was significantly higher both in 1cc and 2cc onion juice subgroups than the control group (p<0.05). There was also increased ovarian stromal VEGF in the 10-day 1cc onion juice subgroup (p<0.05). Conclusion: The results of our study showed that fresh onion juice could increase the number of antral follicles, which is an indicator of enhanced folliculogenesis. © 2021 Bentham Science Publishers.en_US
dc.identifier.citationNafiye Yılmaz, Ayçağ Yorgancı *, Hasan Ali İnal, Banu Seven, Hakan Timur, Müberra Namlı Kalem, Ziya Kalem, Özge Han and Banu Bilezikçi, “Enhancement of Folliculogenesis by Fresh Onion Juice in a Rat Model”, Current Traditional Medicine 2021; 7(3) . https://doi.org/10.2174/2215083806999200819170727en_US
dc.identifier.doi10.2174/2215083806999200819170727en_US
dc.identifier.endpage439en_US
dc.identifier.issn2215-0838en_US
dc.identifier.issn2215-0846en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85116786090en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage434en_US
dc.identifier.urihttps://doi.org/10.2174/2215083806999200819170727
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2166
dc.identifier.volume7en_US
dc.identifier.wosWOS:000712434000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKalem, Ziya
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.relation.ispartofCurrent Traditional Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidative Activityen_US
dc.subjectComplementary Medicineen_US
dc.subjectFolliculogenesisen_US
dc.subjectInfertilityen_US
dc.subjectOnionen_US
dc.subjectPhytotherapyen_US
dc.titleEnhancement of folliculogenesis by fresh onion juice in a rat modelen_US
dc.typeArticleen_US

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