Leptin and leptin receptor gene polymorphisms in obese and healthy children

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dc.authoridGönül Çatlı / 0000-0002-0488-6377en_US
dc.authorscopusidGönül Çatlı / 35783928000
dc.authorwosidGönül Çatlı / EOU-3210-2022
dc.contributor.authorYarım, Ayça Kanat
dc.contributor.authorRasulova, Khayala
dc.contributor.authorÇatlı, Gönül
dc.contributor.authorKüme, Tuncay
dc.contributor.authorAbacı, Ayhan
dc.contributor.authorKızıldağ, Sefa
dc.date.accessioned2022-04-25T08:28:18Z
dc.date.available2022-04-25T08:28:18Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The of this study is to explore the differences between leptin (LEPG2548A), which is considered efficacious in respect of adiposity and leptin receptor gene variants (LEPRQ223R, K109R, K656N). Furthermore, the relationship between these differences and the serum leptin level shall be scrutinized. Materials and Methods: A total of 300 volunteers (12-17 years of age) joined our study (150controls-150obese). Blood samples obtained from these individuals were used for DNA isolation. An examination was carried out in order to show polymorphisms of the leptin receptor gene increased by RealTime PCR previously. The variations of the leptin gene were ascertained by implementation of restriction fragment length polymorphism method. Results: Genotype dispersion calculations led to the understanding that the AA-genotype was lower in the K109R polymorphism control group than in the patient group, whereas AG-genotype was higher. The control group of Q223R polymorphism had higher AA-genotype values than the patient group, whereas it showed lower AG-genotype values. Moreover, anthropometric and metabolic results were found to be significantly higher (p in the patient group than in the control group. Conclusion: The patient group of LEPRQ223R polymorphism showed lower AA-genotype values, a higher AG-genotype dispersion and a higher allele-G value. Therefore, a relationship to adiposity has been assumed.en_US
dc.identifier.citationYarim, A. K., Rasulova, K., Catli, G., Kume, T., Abaci, A., Kizildag, S. (2022). Leptin and leptin receptor gene polymorphisms in obese and healthy children. Cukurova Medical Journal, 47(1), 71-78.en_US
dc.identifier.doi10.17826/cumj.977534en_US
dc.identifier.endpage78en_US
dc.identifier.issn2602-3032en_US
dc.identifier.issue1en_US
dc.identifier.startpage71en_US
dc.identifier.trdizinid519945en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.977534
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2648
dc.identifier.volume47en_US
dc.identifier.wosWOS:000767959700010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorÇatlı, Gönül
dc.language.isoenen_US
dc.publisherCUKUROVA UNIVen_US
dc.relation.ispartofCUKUROVA MEDICAL JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLeptinen_US
dc.subjectLeptin Receptoren_US
dc.subjectObesityen_US
dc.subjectPolymorphismen_US
dc.titleLeptin and leptin receptor gene polymorphisms in obese and healthy childrenen_US
dc.typeArticleen_US

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