Expressions of MMP2, MMP9, and TIMP-1 in the inflammatory cells of nasal polyps: granulocytes, monocytes, and mast cells

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dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.authorwosidBAYAR MULUK, NURAY/JJE-2906-2023
dc.contributor.authorMuluk, N. Bayar
dc.contributor.authorArikan, O. K.
dc.contributor.authorAtasoy, P.
dc.contributor.authorKilic, R.
dc.contributor.authorYalcinozan, E. Tuna
dc.date.accessioned2024-05-19T14:45:46Z
dc.date.available2024-05-19T14:45:46Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractOBJECTIVE: We investigated the role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in nasal polyp (NP) pathogenesis. PATIENTS AND METHODS: In group 1 (n = 24), polyp specimens were obtained from maxillary sinus, ethmoid sinus, and nasal cavity. In group 2 without NP (control) (n = 11), inferior turbinate samples were taken. Inflammatory cell count and MMP2, MMP9 and tissue inhibitor of metalloproteinase-1 ( TIMP-1), positivity indexes (PIs) were evaluated. RESULTS: Granulocyte and mast cell-MMP2 and MMP9-PI were higher than the rate of monocyte-MMP2-PI and monocyte-MMP9-PI, respectively, in the ethmoid sinus, maxillary sinus, and nasal cavity. Mast Cell-TIMP1-PI was higher than the rates of granulocyte-TIMP1-PI and monocyte-TIMP1-PI in the maxillary sinus and was higher than the rate of monocyte-TIMP1-PI in the ethmoid sinus. CONCLUSIONS: Excessive MMP2 and MMP9, compared to TIMP1, are present in granulocytes and mast cells, respectively. With matrix MMPs, the extracellular matrix is destroyed, leading inflammatory cells to pass through, causing polypoid degeneration.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination Unit Funds [2009/16]en_US
dc.description.sponsorshipThis study was supported by Kirikkale University Scientific Research Projects Coordination Unit Funds (Date: 2009, No.: 2009/16).en_US
dc.identifier.endpage20en_US
dc.identifier.issn1128-3602
dc.identifier.pmid37350687en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5336
dc.identifier.volume27en_US
dc.identifier.wosWOS:001011478000002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMatrix Metalloproteinase-2 (Mmp-2)en_US
dc.subjectMatrix Metalloproteinase-9 (Mmp-9)en_US
dc.subjectTissue Inhibitor Of Metalloproteinase-1 (Timp-1)en_US
dc.subjectInflammatory Cellsen_US
dc.subjectNasal Polypen_US
dc.titleExpressions of MMP2, MMP9, and TIMP-1 in the inflammatory cells of nasal polyps: granulocytes, monocytes, and mast cellsen_US
dc.typeArticleen_US

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