Changing trends in the etiology of cirrhosis in Türkiye: a multicenter nationwide study

Basit Öğe Kaydı
dc.authorscopusidEylem Karatay / 36113631800
dc.authorwosidEylem Karatay / AGJ-7943-2022
dc.contributor.authorÜçbilek, Enver
dc.contributor.authorYıldırım, Abdullah Emre
dc.contributor.authorEllik, Zeynep
dc.contributor.authorTuran, İlker
dc.contributor.authorHaktanıyan, Büşra
dc.contributor.authorKaratay, Eylem
dc.date.accessioned2025-06-03T13:39:30Z
dc.date.available2025-06-03T13:39:30Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground/Aims: The aim of our study was to investigate the underlying causes behind the etiology of cirrhosis in T & uuml;rkiye.Materials and Methods: The study was comprised of patients with cirrhosis located in the gastroenterology clinics of 28 centers in T & uuml;rkiye between January 2000 and June 2021. Results: The study group consisted of 4953 cirrhotic patients (median age: 62.2 years, male / female: 58% / 42%). Among the patients, 39% of the patients were compensated, and 61% were decompensated. Furthermore, 47.5% had Child-Pugh class A, 38% had Child-Pugh class B, and 14.5% had Child-Pugh class C. The most frequent complaints were abdominal bloating (28%). Ascites (54.2%) was the most common manifestation of decompensation. The median Child-Pugh and MELD-Na scores were 7.0 and 10.0, respectively. The most common cause of cirrhosis was chronic viral hepatitis (43%), followed by cryptogenic cirrhosis (CC) (19%), metabolic dysfunc-tion-associated steatotic liver disease (MASLD)-related cirrhosis (13%), and alcohol-related cirrhosis (11%). Among the 950 patients with CC, 416 had metabolic abnormalities. If these 416 CC patients with metabolic abnormalities were categorized as having MASLD-related cirrhosis, the proportion of MASLD-related cirrhosis increased to 21%. Thirteen percent of the patients were diagnosed with HCC, while 4% had extrahepatic malignancy. Female breast cancer (18%) and colorectal cancer (18%) were the most frequent extra-hepatic malignancies. Conclusion: Viral hepatitis remains the main cause of cirrhosis in T & uuml;rkiye. However, its prevalence seems to be declining, whereas the prevalence of steatotic liver disease-related cirrhosis is increasing
dc.identifier.citationÜçbilek, E., Yıldırım, A. E., Ellik, Z., Turan, İ., Haktanıyan, B., Orucu, B., ... & Idilman, R. (2024). Changing trends in the etiology of cirrhosis in Türkiye: a multicenter nationwide study. The Turkish Journal of Gastroenterology, 35(10), 772.
dc.identifier.doi10.5152/tjg.2024.23572
dc.identifier.endpage777
dc.identifier.issn2148-5607
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85205994317
dc.identifier.scopusqualityQ3
dc.identifier.startpage772
dc.identifier.urihttp://dx.doi.org/10.5152/tjg.2024.23572
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7286
dc.identifier.volume35
dc.identifier.wosWOS:001344200200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKaratay, Eylem
dc.institutionauthoridEylem Karatay / 0000-0003-3738-3554
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish journal of gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCirrhosis
dc.subjectEtiology
dc.subjectHepatocellular Carcinoma
dc.subjectMetabolic Dysfunction-Associated Steatotic Liver Disease
dc.subjectViral Hepatitis
dc.titleChanging trends in the etiology of cirrhosis in Türkiye: a multicenter nationwide study
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
TJG_20230572_nlm_new_indd(1).pdf
Boyut:
1.44 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Dahili Tıp Bilimleri Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu