Fetal brain lactate peak measurement by magnetic resonance spectroscopy for prediction of fetal hypoxia in a case of unexplained third trimester recurrent fetal loses

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dc.authoridBertan Akar / 0000-0003-0494-6867
dc.authorscopusidBertan Akar / 56439873300
dc.authorwosidBertan Akar / CCD-2869-2022
dc.contributor.authorAkar, Bertan
dc.contributor.authorAslancan, Reyhan
dc.contributor.authorŞimşek, Hakkı
dc.contributor.authorÇakır, Pınar
dc.contributor.authorÇalışkan, Eray
dc.date.accessioned2020-08-30T20:07:05Z
dc.date.available2020-08-30T20:07:05Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Ebelik Bölümüen_US
dc.description.abstractBackground: The fetal brain lactate level which is measured by magnetic resonance spectroscopy (MRS) is a compelling indicator for hypoxic/ischemic brain damage. Aim: The authors present a case of MRS diagnosed fetal brain lactate peak despite normal fetal development and Doppler indices which lead to a preterm delivered hypoxic fetus. Case Report: A 37-year-old woman admitted to this clinic at 30 weeks six days of her gestation because of previous recurrent three unexplained fetal death at third trimester and one neonatal death. At 33 weeks one day of pregnancy. MRS examination showed lactate peak in the fetal brain, despite bi-weekly normal Doppler indices and fetal biophysical profile follow-up. After eight days of daily follow-up since lactate peak measurement, her biophysical profile was 6 despite normal Doppler indices. She developed mild preeclampsia after four days following lactate peak. She had imminent cesarean section at 34th week of gestation and a 1,980-gram neonate with Apgar scores of 5 and 7 at the first and fifth minute was delivered. Fetal hypoxia was diagnosed due to base excess of -14 and a cord blood pH of 7.16. The newborn was discharged in a healthy state after five days of neonatal intensive care. Conclusion: The case presents that fetal brain lactate peak can be the only first warning sign in cases of unexplained fetal losses predicting oncoming fetal hypoxia despite normal fetal Doppler and biophysical profile evaluation.en_US
dc.identifier.citationAkar, B., Aslancan, R., Simsek, H., Cakir, P., & Caliskan, E. (2019). Fetal brain lactate peak measurement by magnetic resonance spectroscopy for prediction of fetal hypoxia in a case of unexplained third trimester recurrent fetal loses. CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 46(2), 302–304. https://doi.org/10.12891/ceog4464.2019en_US
dc.identifier.doi10.12891/ceog4464.2019en_US
dc.identifier.endpage304en_US
dc.identifier.issn0390-6663en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85067061511en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.12891/ceog4464.2019
dc.identifier.urihttps://hdl.handle.net/20.500.12713/692
dc.identifier.volume46en_US
dc.identifier.wosWOS:000474747400028en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAkar, Bertanen_US
dc.language.isoenen_US
dc.publisher7847050 Canada Incen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleFetal brain lactate peak measurement by magnetic resonance spectroscopy for prediction of fetal hypoxia in a case of unexplained third trimester recurrent fetal losesen_US
dc.typeArticleen_US

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