Assessment of oxidative stress effects in serum determined by FT-IR spectroscopy in cholangiocarcinoma patients

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300en_US
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.contributor.authorBulut, Huri
dc.contributor.authorTarhan, Nevzat
dc.contributor.authorBüyük, Melek
dc.contributor.authorSerin, Kürşat Rahmi
dc.contributor.authorUlukaya, Engin
dc.contributor.authorDepciuch, Joanna
dc.contributor.authorParlinska-Wojtan, Magdalena
dc.contributor.authorGüleken, Zozan
dc.date.accessioned2022-05-31T08:14:12Z
dc.date.available2022-05-31T08:14:12Z
dc.date.issued2023en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractCholangiocarcinoma (CCA) is a heterogeneous malignant tumor containing intrahepatic and extrahepatic bile ducts and gallbladder carcinoma. Mostly diagnosed at an advanced stage with a <5% cure chance. Early-stage diagnosis may increase the number of patients who reach curative treatment. Fourier Transform InfraRed (FT-IR) spectroscopy was used to detect chemical changes in serum collected from CCA patients vs. healthy individuals. The study aims to correlate the FTIR spectra with biochemical indices such as TAS, TOS, OSI, and total protein levels. Decreased TAS and increased TOS, OSI, and total protein levels in CCA patients vs. healthy individuals were found. FTIR spectra showed higher absorbance of the peaks corresponding to C–O and bending vibration of C–O–H groups in CCA patients, while more CH2 functional groups than lipids could be seen in the FTIR spectra of controls serum. PLS analysis showed IR ranges of 1500 cm-1 to 1700 cm-1, and 2700 cm-1 to 3000 cm-1 were able to distinguish between CCA from controls, respectively. PCA confirmed this, while HCA did not differentiate between CCA and those without the disease. Lipids and some functional groups changes caused by oxidative stress can be applied to predict CCA by using FTIR spectroscopy. © 2022 by the authors.en_US
dc.identifier.citationBulut, H., Tarhan, N., Büyük, M., Serin, K. R., Ulukaya, E., Depciuch, J., . . . Guleken, Z. (2023). Assessment of oxidative stress effects in serum determined by FT-IR spectroscopy in cholangiocarcinoma patients. Biointerface Research in Applied Chemistry, 13(2) doi:10.33263/BRIAC132.151en_US
dc.identifier.doi10.33263/BRIAC132.151en_US
dc.identifier.issn2069-5837en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-851284367en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.33263/BRIAC132.151
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2755
dc.identifier.volume13en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.publisherAMG Transcend Associationen_US
dc.relation.ispartofBiointerface Research in Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCholangiocarcinomaen_US
dc.subjectFourier Transform InfraReden_US
dc.subjectOxidative Loaden_US
dc.subjectTotal Proteinen_US
dc.titleAssessment of oxidative stress effects in serum determined by FT-IR spectroscopy in cholangiocarcinoma patientsen_US
dc.typeArticleen_US

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