Preparation and characterization of PBS (polybutylene succinate) nanoparticles containing cannabidiol (CBD) for anticancer application

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorFreire, Natalia Freitas
dc.contributor.authorCordani, Marco
dc.contributor.authorAparicio-Blanco, Juan
dc.contributor.authorSanchez, Ana Isabel Fraguas
dc.contributor.authorDutra, Luciana
dc.contributor.authorPinto, Martina C. C.
dc.contributor.authorZarrabi, Ali
dc.contributor.authorPinto, Jose Carlos
dc.contributor.authorVelasco, Guillermo
dc.contributor.authorFialho, Rosana
dc.date.accessioned2025-04-18T10:25:46Z
dc.date.available2025-04-18T10:25:46Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractCannabidiol (CBD), a major constituent of Cannabis sativa, has demonstrated a broad range of therapeutic properties in human studies. Notably, CBD has shown anticancer activity in preclinical cancer models. However, its low water solubility poses challenges for bioavailability, necessitating the development of drug delivery systems to enhance its efficacy. This study aimed to create CBD-loaded Poly (butylene succinate) (PBS) nanoparticles and evaluate their effectiveness in in vitro cancer models. The nanoparticles, with an average size of 175 nm, were produced using a modified double emulsion/solvent evaporation technique. The release profile of CBD from the nanoparticles exhibited an initial rapid release followed by a slower sustained release. Cytotoxicity assays demonstrated that the CBD-PBS nanoparticles retained the anticancer effects of free CBD, selectively reducing the viability of cancer cell lines without affecting non -transformed fibroblasts. Additionally, the nanoformulation modulated key cellular pathways, as indicated by decreased AKT phosphorylation and increased LC3-II levels, suggesting that the encapsulated CBD preserved its ability to induce autophagy-mediated cell death in cancer cells. The nanoformulation also effectively inhibited cell migration in highly invasive prostate cancer cells, mirroring the effects of free CBD, while not impacting the migration of non -tumoral fibroblasts. These results underscore the therapeutic potential of this CBD nanoformulation, setting the stage for further in vivo investigations.
dc.description.sponsorshipFundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.identifier.citationFreire, N. F., Cordani, M., Aparicio-Blanco, J., Sanchez, A. I. F., Dutra, L., Pinto, M. C., ... & Fialho, R. (2024). Preparation and characterization of PBS (Polybutylene Succinate) nanoparticles containing cannabidiol (CBD) for anticancer application. Journal of Drug Delivery Science and Technology, 105833.
dc.identifier.doi10.1016/j.jddst.2024.105833
dc.identifier.endpage11
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85195020063
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.jddst.2024.105833
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7060
dc.identifier.volume97
dc.identifier.wosWOS:001251252500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of drug delivery science and technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPoly-Butylene Succinate
dc.subjectEnvironmentally Friendly Polymers
dc.subjectNanoparticles
dc.subjectDrug Delivery
dc.subjectCannabidiol
dc.subjectCancer Cells
dc.titlePreparation and characterization of PBS (polybutylene succinate) nanoparticles containing cannabidiol (CBD) for anticancer application
dc.typeArticle

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