Comparing the potential effects of standardized heparin sodium and tinzaparin sodium on microvascular thrombosis in the late phase of intraabdominal sepsis

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dc.authoridÖmer Vefik Özozan / 0000-0001-5885-7865
dc.authorscopusidÖmer Vefik Özozan / 20434255000
dc.authorwosidÖmer Vefik Özozan / AAU-4795-2020
dc.contributor.authorÖzozan, Ömer Vefik
dc.contributor.authorKarakahya Murat
dc.contributor.authorKülah Bahadır
dc.contributor.authorCoşkun Faruk
dc.date.accessioned2020-08-30T20:01:37Z
dc.date.available2020-08-30T20:01:37Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionOzozan, Omer Vefik (isu author)
dc.description.abstractAim of the Study: The aim of this study is to compare the potential effects of standardized heparin sodium and tinzaparin sodium, which is a member of low molecular weight heparin (LMWH), on microvascular thrombosis in the late phase of intraabdominal polimicrobial sepsis on an experimental model of caecal ligation and puncture. Material and Methods: Thirty Wistar albino rats with an average weight of 250-300 gr were divided into 5 groups in a randomized fashion: Control (C) group (6 rats), caecal ligation and puncture (CLP) group (6 rats), conventional heparin (H) group (6 rats), tinzaparin sodium (T) group (6 rats), combined heparin and tinzaparin sodium (H+T) group (6 rats). Only laparotomy was done to rats in the control group. CLP of Wichterman’s was done to all other groups. After 2 hours 200 IU/kg of heparin sodium to all rats in the H group, 200 IU/kg of tinzaparin sodium to all rats in the T group, 100IU/kg heparin sodium and 100 IU/kg tinzaparin sodium to all rats in the H+T group were injected subcutaneously. All rats were sacrified 24 hours after CLP. Blood samples for leucocyte counts, thrombocyte counts, hemoglobin levels, antithrombin-III levels were obtained. Lung and intestinal tissue samples were obtained for histopathological investigation. All the tissue samples were assessed by the same pathologist who is unaware of the groups. All the data obtained were analyzed by SPSS version 13.0 Windows program, intergoup differences were analyzed by Kruskal Wallis and Mann Whitney U nonparametric tests. Results: Leucocyte levels at 24. hour in all groups were found to be statistically higher than the leucocyte levels in the C group. Thrombocyte levels at 24. hour in all groups were found to be statistically lower than the C group. Thrombocyte levels in the H group, T group and H+T group were statistically higher than the thrombocyte levels in CLP group. Antithrombin-III levels at 24. hour in all groups were found to be statistically lower than the antithrombin-III levels in the C group. Antithrombin-III levels in the T group were statistically higher than the antithrombin-III levels in the H group. In all treatment groups microvascular thrombosis in lung and intestinal tissue samples were lower than the C group whereas the effects of heparin sodium and tinzaparin on inhibiton of microvascular thrombosis were found to be similar. There was no difference between treatment groups and control group when inhibition of late phase inflammation is regarded. Conclusion: While inhibiting microvascular thrombosis, anticoagulant therapy does not prevent sepsis induced inflammation. Anticoagulant treatments may be adjunctive rather than a definitive treatment in sepsis. Tinzaparin sodium may be a more appropriate choice in microvascular thrombosis treatment in sepsis since it offers a lower hemorrhage risk than unfractioned heparin with a similar antithrombotic potential. © 2019 Surgical Society of Northern Greece. All rights reserved.en_US
dc.identifier.citationOzozan, O. V., Karakahya, M., Külah, B., & Coşkun, F. (2019). Comparing the potential effects of standardized heparin sodium and tinzaparin sodium on microvascular thrombosis in the late phase of intraabdominal sepsis.en_US
dc.identifier.endpage60en_US
dc.identifier.issn1108-5002en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/323
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖzozan, Ömer Vefiken_US
dc.language.isoenen_US
dc.publisherSurgical Society of Northern Greeceen_US
dc.relation.ispartofSurgical Chroniclesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeparin Sodiumen_US
dc.subjectSepsisen_US
dc.subjectThrombosisen_US
dc.subjectTinzaparin Sodiumen_US
dc.titleComparing the potential effects of standardized heparin sodium and tinzaparin sodium on microvascular thrombosis in the late phase of intraabdominal sepsisen_US
dc.typeArticleen_US

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