Synthesis, characterization, in vitro cytotoxicity of novel metallo phthalocyanines with four methylpropiophenonyl clusters and their effects on caenorhabditis elegans thermotolerance

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dc.authoridSema Şenoğlu / 0000-0002-1618-6570en_US
dc.authoridMeltem Güleç / 0000-0002-3291-4304en_US
dc.authoridBekir Salih / 0000-0002-8542-6531en_US
dc.authoridElif Yavuz Dokgöz / 0000-0002-5095-8474en_US
dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridBurçin İzbudak / 0000-0002-5572-7966en_US
dc.authoridAbdullah Olgun / 0000-0002-6976-9286en_US
dc.authoridTanju Ceyhan / 0000-0003-2395-7641en_US
dc.authorscopusidSema Şenoğlu / 57214886928en_US
dc.authorscopusidMeltem Güleç / 57284570200en_US
dc.authorscopusidBekir Salih / 7005901994en_US
dc.authorscopusidElif Yavuz Dokgöz / 57284790900en_US
dc.authorscopusidAyça Bal Öztürk / 57062000100en_US
dc.authorscopusidBurçin İzbudak / 57221779519en_US
dc.authorscopusidAbdullah Olgun / 57210603133en_US
dc.authorscopusidTanju Ceyhan / 8273726800en_US
dc.authorwosidSema Şenoğlu / GER-4167-2022en_US
dc.authorwosidMeltem Güleç / M-4510-2018en_US
dc.authorwosidBekir Salih / GAK-6065-2022en_US
dc.authorwosidElif Yavuz Dokgöz / HFL-6558-2022en_US
dc.authorwosidAyça Bal Öztürk / M-4472-2018en_US
dc.authorwosidBurçin İzbudak / GXP-7807-2022en_US
dc.authorwosidAbdullah Olgun / FPP-8980-2022en_US
dc.authorwosidTanju Ceyhan / HEB-7998-2022en_US
dc.contributor.authorŞenoğlu, Sema
dc.contributor.authorGüleç, Meltem
dc.contributor.authorYavuz Dokgöz, Elif
dc.contributor.authorBal Öztürk, Ayça
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorSalih, Bekir
dc.contributor.authorOlgun, Abdullah
dc.contributor.authorCeyhan, Tanju
dc.date.accessioned2022-12-08T08:09:10Z
dc.date.available2022-12-08T08:09:10Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractPhthalocyanines (Pcs) have the potential to be used in many medical applications. Novel Zn (II), Co (II), and Cu (II) phthalocyanines (Pcs) 4, 5, and 6, respectively, containing four methylpropiophenonyl units at the peripheral positions were described. Pcs were synthesized by cyclotetramerization of the previously prepared precursor 2-hydroxy-4'-[2-(3,4-dicyanophenoxyethoxy)]-2-methylpropiophenone 3 with the presence of metal salts under nitrogen atmosphere. The compounds were characterized by elemental analysis, IR (Infrared spectroscopy), UV-visible spectroscopy, and Laser Desorption ionization time-of-flight mass spectroscopy (LDI-TOF-MS) methods. The compounds were tested for in vitro cytotoxicity in cultured human cells, and thermotolerance in Caenorhabditis elegans (C. elegans). Standard MTT assays were carried out for cytotoxicity testing using HeLa and L929 cells. Results showed that there was no significant decrease in the cell viability with zinc (II), cobalt (II), and copper (II) phthalocyanines (ZnPc, CoPc, and CuPc) at 0.25 mu M concentration. C. elegans survival assay with ZnPc, CoPc, and CuPc under heat stress showed that although a dose-dependent statistically significant toxicity was observed for ZnPc and CuPc, CoPc was not toxic at all concentrations tested and even increased the survival of worms at the 0.050-0.250 mu M concentration range. Therefore, CoPc can be a lead compound for further preclinical studies for its potential in photodynamic therapy (PDT) and anti-aging purposes.en_US
dc.identifier.citationŞenoğlu, S., Güleç, M., Dokgöz, E. Y., Öztürk, A. B., İzbudak, B., Salih, B., ... & Ceyhan, T. (2022). Synthesis, characterization, in vitro cytotoxicity of novel metallo phthalocyanines with four methylpropiophenonyl clusters and their effects on Caenorhabditis elegans thermotolerance. Chemical Papers, 1-12.en_US
dc.identifier.doi10.1007/s11696-022-02415-6en_US
dc.identifier.issn0366-6352en_US
dc.identifier.issn2585-7290en_US
dc.identifier.scopus2-s2.0-85141618728en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s11696-022-02415-6
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3425
dc.identifier.wosWOS:000880569400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorŞenoğlu, Sema
dc.institutionauthorGüleç, Meltem
dc.institutionauthorYavuz Dokgöz, Elif
dc.institutionauthorBal Öztürk, Ayça
dc.institutionauthorİzbudak, Burçin
dc.institutionauthorSalih, Bekir
dc.institutionauthorOlgun, Abdullah
dc.institutionauthorCeyhan, Tanju
dc.language.isoenen_US
dc.publisherSPRINGER INT PUBL AGen_US
dc.relation.ispartofCHEMICAL PAPERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhthalocyaninesen_US
dc.subjectCytotoxicityen_US
dc.subjectC. Elegansen_US
dc.subjectCell Cultureen_US
dc.subjectThermotoleranceen_US
dc.titleSynthesis, characterization, in vitro cytotoxicity of novel metallo phthalocyanines with four methylpropiophenonyl clusters and their effects on caenorhabditis elegans thermotoleranceen_US
dc.typeArticleen_US

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