Amine-functionalized mesoporous silica nanoparticles decorated by silver nanoparticles for delivery of doxorubicin in breast and cervical cancer cells

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorGhobadi, Melika
dc.contributor.authorSalehi, Saeideh
dc.contributor.authorArdestani, Mohammad Taha Salmanifard
dc.contributor.authorMousavi-Khattat, Mohammad
dc.contributor.authorShakeran, Zahra
dc.contributor.authorKhosravi, Arezoo
dc.contributor.authorCordani, Marco
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2025-04-18T09:53:08Z
dc.date.available2025-04-18T09:53:08Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractNanocarriers have demonstrated promising potential in the delivery of various anticancer drugs and in improving the efficiency of the treatment. In this study, silver nanoparticles (AgNPs) were green-synthesized using the extracts of different parts of the pomegranate plant, including the peel, flower petals, and calyx. To obtain the most efficient extract used for the green synthesis of AgNPs, all three types of synthesized nanoparticles were characterized. Then, (3-Aminopropyl) triethoxysilane-functionalized mesoporous silica nanoparticles (MSNs-APTES) decorated with AgNPs were fabricated via a one-pot green-synthesis method. AgNPs were directly coated on the surface of MSNs-APTES by adding pomegranate extract enriched with a source of reducing agent leading to converting the silver ion to AgNPs. The MSN-APTES-AgNPs (MSNs-AgNPs) have been thoroughly characterized using nanoparticle characterization techniques. In addition, DNA cleavage and hemolysis activities of the synthesized nanoparticles were analyzed, confirming the biocompatibility of synthesized nanoparticles. The Doxorubicin (DOX, as a breast/cervical anti-cancer drug) loading (42.8%) and release profiles were investigated via UV-visible spectroscopy. The fibroblast, breast cancer, and cervical cancer cells' viability against DOX-loaded nanoparticles were also studied. The results of this high drug loading, uniform shape, and small functionalized nanoparticles demonstrated its great potential for breast and cervical cancer management.
dc.description.sponsorshipEuropean Union (EU)
dc.identifier.citationGhobadi, M., Salehi, S., Ardestani, M. T. S., Mousavi-Khattat, M., Shakeran, Z., Khosravi, A., ... & Zarrabi, A. (2024). Amine-functionalized mesoporous silica nanoparticles decorated by silver nanoparticles for delivery of doxorubicin in breast and cervical cancer cells. European Journal of Pharmaceutics and Biopharmaceutics, 114349.
dc.identifier.doi10.1016/j.ejpb.2024.114349
dc.identifier.endpage14
dc.identifier.issn0939-6411
dc.identifier.issn1873-3441
dc.identifier.scopus2-s2.0-85196748841
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.ejpb.2024.114349
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6888
dc.identifier.volume201
dc.identifier.wosWOS:001260895800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean journal of pharmaceutics and biopharmaceutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMesoporous Silica Nanoparticles
dc.subjectSilver Nanoparticles
dc.subjectGreen Synthesis
dc.subjectDoxorubicin
dc.subjectBreast Cancer
dc.subjectCervical Cancer
dc.titleAmine-functionalized mesoporous silica nanoparticles decorated by silver nanoparticles for delivery of doxorubicin in breast and cervical cancer cells
dc.typeArticle

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