Nonapoptotic cell death induced by Hypericum species on cancer cells

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorArı, Ferda
dc.contributor.authorAztopal, Nazlıhan
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorÇelikler, Serap
dc.contributor.authorŞahin, Saliha
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-09-25T12:06:30Z
dc.date.available2020-09-25T12:06:30Z
dc.date.issued2017en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives. There are approximately 400 Hypericum species that grow naturally in different geographic originsof the world. Those species have been used in different folk medicines and screened for their biological activityincluding cancer. Our country is an important place for Hypericum species which are known as “kantaron,binbirdelik otu, kan otu, kılıç otu, yaraotu, kuzukıran”. We therefore evaluated the possible cytotoxic/apoptoticactivities, total phenolic content and antioxidant capacity of the crude methanol extracts Hypericumadenotrichum Spach. and Hypericum olympicum L. which are still used in Turkish folk medicine. Methods.The total phenolic content and antioxidant capacity were determined by Folin-Ciocalteu and ABTS methods.Anti-growth effects were screened in human hepatoma (Hep3B) and rat glioma (C6) cell lines by the MTTand ATP viability assays. The cell death mode (apoptosis/necrosis) was investigated by fluorescence imagingand the level of caspase-cleaved cytokeratin 18 (M30), active caspase-3 and cleaved PARP (poly (ADP-ribose)polymerase). Results. The results indicate that the crude methanol extracts of Hypericum olympicum L. andHypericum adenotrichum have both anti-growth/cytotoxic activities on these cells in a dose dependent manner.Conclusion. These extracts clearly induced non-apoptotic cell death in human hepatoma (Hep3B) and ratglioma (C6) cell linesen_US
dc.identifier.citationARI F,AZTOPAL N,ERKİSA M,ÇELİKLER S,ŞAHİN S,ULUKAYA E (2017). Nonapoptotic cell death induced by Hypericum species on cancer cells. The European Research Journal, 3(1), 1 - 10.en_US
dc.identifier.endpage10en_US
dc.identifier.issn2149-3189en_US
dc.identifier.issn2149-3189en_US
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.trdizinid257472en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1113
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorUlukaya, Engin
dc.language.isoenen_US
dc.relation.ispartofThe European Research Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypericum Olympicumen_US
dc.subjectHypericum Adenotrichumen_US
dc.subjectCell Deathen_US
dc.subjectNecrosisen_US
dc.titleNonapoptotic cell death induced by Hypericum species on cancer cellsen_US
dc.typeArticleen_US

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