Cytotoxic effects of n-(4-chlorophenyl)-1h-ındole-2-carboxamide on bone cancer cells

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dc.authoridHakan Darıcı / 0000-0001-9393-554X
dc.authorscopusidHakan Darıcı / 22333489600
dc.authorwosidHakan Darıcı / AAG-4316-2019
dc.contributor.authorTasdemir, Medine
dc.contributor.authorOzgurses, Mete Emir
dc.contributor.authorDarıcı, Hakan
dc.contributor.authorOrdueli, Nazli Ece
dc.date.accessioned2020-12-07T08:22:53Z
dc.date.available2020-12-07T08:22:53Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractINTRODUCTION:Osteosarcoma is a common tumor of high malignancy, usually derived from mesenchymal tissues. The lack of response to chemotherapeutic treatments indicates the importance of investigating new therapeutic methods. Indole, which is known to inhibit proliferation on cancer cells, is new synthesized as a derivative of this molecule of N-(4-chlorophenyl) -lH-indole-2-carboxamide, has an effect on osteosarcoma cell line. We evaluated the cytotoxic effects of N-(4-chlorophenyl) -1H-indole-2-carboxamide by verification of pharmacological doses of imatinib mesylate based on time on osteosarcoma cells.METHODS:In the present study, the effects of N-(4-chlorophenyl)-1H-indole-2-carboxamide and Imatinib mesylate doses on cell viability of osteosarcoma Saos-2 cells were conducted using MTT assay. Ezrin expression levels was examined by immunofluorescence staining.RESULTS:The results of the antiproliferative activity showed that N-(4-chlorophenyl) -1 H-indole-2-carboxamide inhibited cell proliferation of Saos-2 cells in a dose-and time-dependent manner. We found that even lower doses of N-(4-chlorophenyl) -1H-indole-2-carboxamide was effective on osteosarcoma cell lines when we compared with imatinib mesylate pharmacological doses.DISCUSSION AND CONCLUSION:In this study, for the first time the newly synthesized indole derivative molecule, N-(4-chlorophenyl) -1 H-indole-2-carboxamide was evaluated for resistance in vitro Saos-2 cell line. All these results showed that N-(4-Chlorophenyl) -1 H-Indole-2-Carboxamide can be developed as a potential therapeutic agent for inhibiting osteosarcoma growth and metastasisen_US
dc.identifier.citationTAŞDEMİR M,ÖZGÜRSES M. E,DARICI H,ORDUERİ N. E (2020). Cytotoxic Effects Of N-(4-Chlorophenyl)-1H-Indole-2-Carboxamide On Bone Cancer Cells. ACTA ONCOLOGICA TURCICA, 53(1), 173 - 180. Doi: 10.5505/aot.2020.20591en_US
dc.identifier.doi10.5505/aot.2020.20591en_US
dc.identifier.endpage180en_US
dc.identifier.issn304-596Xen_US
dc.identifier.issn2148-7669en_US
dc.identifier.issue1en_US
dc.identifier.startpage173en_US
dc.identifier.trdizinid381966en_US
dc.identifier.urihttps://doi.org/10.5505/aot.2020.20591
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1265
dc.identifier.volume53en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorDarıcı, Hakan
dc.language.isoenen_US
dc.relation.ispartofACTA ONCOLOGICA TURCICAen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOsteosarcomaen_US
dc.subjectN-(4-Chlorophenyl)-1H-Indole-2-Carboxamideen_US
dc.subjectCell Proliferationen_US
dc.subjectReactive Oxygen Speciesen_US
dc.subjectThyrosine Kinasesen_US
dc.titleCytotoxic effects of n-(4-chlorophenyl)-1h-ındole-2-carboxamide on bone cancer cellsen_US
dc.typeArticleen_US

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