Systemic Inflammation Score for Predicting Radiation-Induced Trismus and Osteoradionecrosis of the Jaw Rates in Locally Advanced Nasopharyngeal Carcinoma Patients

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dc.authoridTopkan, Erkan/0000-0001-8120-7123
dc.authoridselek, ugur/0000-0001-8087-3140
dc.authorwosidTopkan, Erkan/AAG-2213-2021
dc.authorwosidselek, ugur/O-5474-2014
dc.contributor.authorSomay, Efsun
dc.contributor.authorSezen, Duygu
dc.contributor.authorSelek, Ugur
dc.contributor.authorBesen, Ali Ayberk
dc.contributor.authorMertsoylu, Huseyin
dc.contributor.authorTopkan, Erkan
dc.date.accessioned2024-05-19T14:45:58Z
dc.date.available2024-05-19T14:45:58Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractWe sought to determine the predictive value of the systemic inflammation score (SIS) for radiation-induced trismus (RIT) and osteora-dionecrosis of the jaw (ORNJ) in locally advanced nasopharyngeal carcinoma (LA-NPC) patients treated with concurrent chemoradio-therapy (C-CRT). LA-NPC patients (n= 188) who underwent C-CRT and pre-and post-C-CRT oral examinations from August 2010 to January 2022 were included. The three-tiered SIS groups were created using the serum albumin and lymphocyte-to-monocyte ratio (LMR) measures obtained on the first day of C-CRT: SIS-0: Albumin >= 40 g/dL and LMR >= 4.44); SIS-1: Albumin < 40 g/dL and LMR < 4.44 or albumin >= 0 g/dL and LMR >= 4.44; and SIS-2: Albumin < 40 g/dL and LMR <4.44. The primary objective was to ascertain whether there were irrefutable associations between pretreatment SIS groups and the respective post-C-CRT RIT and ORNJ rates. RIT and ORNJ were diagnosed in 33 (17.6%) and 21 (11.1%) patients, respectively. There were 12 (32.4%), 13 (12.7%), and 18 (45.0%) cases diagnosed with RIT in the respective SIS-0, SIS-1, and SIS-2 groups (p< 0.001). Similarly, there were 1 (2.7%), 11 (9.9%), and 9 (22.5%) cases with ORNJ diagnoses in the corresponding SIS groups (p< 0.001). The multivariate analysis's findings revealed that the SIS grouping was an independent predictor of RIT (p< 0.001) and ORNJ incidence rates (p< 0.001). Our study's findings indicate that the novel pretreatment SIS grouping is a dependable biomarker-based system, which can accurately predict the rates of RIT and ORNJ in LA-NPC patients who receive definitive C-CRT.en_US
dc.identifier.doi10.4999/uhod.237293
dc.identifier.endpage169en_US
dc.identifier.issn1306-133X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85175575345en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org10.4999/uhod.237293
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5408
dc.identifier.volume33en_US
dc.identifier.wosWOS:001085924200006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.subjectSystemic Inflammation Scoreen_US
dc.subjectRadiation-Induced Trismusen_US
dc.subjectOsteoradionecrosisen_US
dc.subjectBiomarkeren_US
dc.titleSystemic Inflammation Score for Predicting Radiation-Induced Trismus and Osteoradionecrosis of the Jaw Rates in Locally Advanced Nasopharyngeal Carcinoma Patientsen_US
dc.typeArticleen_US

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