Nasopharyngeal meningococcal carriage among children and adolescents in Turkey in 2018: an unexpected high serogroup x carriage

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dc.authoridMurat Sütçü / 0000-0002-2078-9796
dc.authorscopusidMurat Sütçü / 55499199300
dc.authorwosidMurat Sütçü / AAR-5212-2020
dc.contributor.authorKızıl, Mahmut Can
dc.contributor.authorKılıç, Ömer
dc.contributor.authorCeylan, Mehmet
dc.contributor.authorIseri Nepesov, Merve
dc.contributor.authorKarbuz, Adem
dc.contributor.authorKurugöl, Zafer
dc.contributor.authorSütçü, Murat
dc.date.accessioned2021-11-02T13:38:18Z
dc.date.available2021-11-02T13:38:18Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractMeningococcal carriage studies and transmission modeling can predict IMD epidemiology and used to define invasive meningococcal disease (IMD) control strategies. In this multicenter study, we aimed to evaluate the prevalence of nasopharyngeal Neisseria meningitidis (Nm) carriage, serogroup distribution, and related risk factors in Turkey. Nasopharyngeal samples were collected from a total of 1267 children and adolescents and were tested with rt-PCR. Nm carriage was detected in 96 participants (7.5%, 95% CI 6.1-9.0), with the peak age at 13 years (12.5%). Regarding age groups, Nm carriage rate was 7% in the 0-5 age group, was 6.9%in the 6-10 age group, was 7.9% in the 11-14 age group, and was 9.3% in the 15-18 age group. There was no statistically significant difference between the groups (p > 0.05). The serogroup distribution was as follows: 25% MenX, 9.4% MenA, 9.4% MenB, 2.1% MenC, 3.1% MenW, 2.1% for MenY, and 48.9% for non-groupable. The Nm carriage rate was higher in children with previous upper respiratory tract infections and with a high number of household members, whereas it was lower in children with antibiotic use in the last month (p < 0.05 for all). In this study, MenX is the predominant carriage strain. The geographical distribution of Nm strains varies, but serogroup distribution in the same country might change in a matter of years. Adequate surveillance and/or a proper carriage study is paramount for accurate/dynamic serogroup distribution and the impact of the proposed vaccination.en_US
dc.identifier.citationKizil, M. C., Kilic, O., Ceyhan, M., Iseri Nepesov, M., Karbuz, A., Kurugol, Z., Hacimustafaoglu, M., Celebi, S., Dinleyici, M., Carman, K. B., Bayhan, C., Balliel, Y., Sutcu, M., Kuyucu, N., Kondolot, M., Kara, S. S., Ocal Demir, S., Cay, U., Gayretli Aydin, Z. G., Kaya, M., … Dinleyici, E. C. (2021). Nasopharyngeal Meningococcal Carriage among Children and Adolescents in Turkey in 2018: An Unexpected High Serogroup X Carriage. Children (Basel, Switzerland), 8(10), 871.en_US
dc.identifier.doi10.3390/children8100871en_US
dc.identifier.issue10en_US
dc.identifier.pmid34682136en_US
dc.identifier.urihttps://doi.org/10.3390/children8100871
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2199
dc.identifier.volume8en_US
dc.identifier.wosWOS:000712875100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSütçü, Murat
dc.language.isoenen_US
dc.publisherPubMed Centralen_US
dc.relation.ispartofChildren (Basel) .en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMenXen_US
dc.subjectNeisseria Meningitidisen_US
dc.subjectCarriageen_US
dc.subjectMeningococcal Carriageen_US
dc.subjectSerogrup Xen_US
dc.titleNasopharyngeal meningococcal carriage among children and adolescents in Turkey in 2018: an unexpected high serogroup x carriageen_US
dc.typeArticleen_US

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