Antioxidant, antimicrobial, anti-urease and cytotoxic activities of various extracts from Scutellaria sibthorpii endemic to Cyprus

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dc.authoridGizem Gülsoy Toplan / 0000-0002-0544-2532
dc.authorscopusidGizem Gülsoy Toplan / 57192304526
dc.authorwosidGizem Gülsoy Toplan / ECA-5991-2022en_US
dc.contributor.authorToplan, Gizem Gülsoy
dc.contributor.authorTaşkın, Turgut
dc.contributor.authorÖztaş, Ezgi
dc.contributor.authorHacıoğlu, Mayram
dc.contributor.authorTufan, Selin
dc.contributor.authorSarıyar, Günay
dc.contributor.authorMat, Afife
dc.date.accessioned2022-09-07T11:12:16Z
dc.date.available2022-09-07T11:12:16Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractLamiaceae is one of the largest families in the plant kingdom. Including the genus Scutellaria whose species are used in traditional medicine in various countries for prevention and also the treatment of several disorders. In vitro biological activities of the various extracts of the aerial parts from Scutellaria sibthorpii were investigated in the present study. Antioxidant activity of the extracts was measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS assays and ferric reducing antioxidant power (FRAP) assays. Cytotoxic potential and anti-urease activities of the extracts were also determined. Spectrophotometric analysis was used to establish the total phenol content of the extracts. The antibacterial activities of extracts were assessed by minimal inhibitory concentration (MIC) against seven bacteria and Candida albicans. Regarding the results, infusion showed considerable antioxidant properties in three method (IC50 value 0.133 +/- 0.0005(DPPH), 26.54 +/- 0.05 mM trolox/mg extract(ABTS), 8.76 +/- 0.1 mM Fe+2/mg extract (FRAP)). Other extracts exhibited high-to-moderate antioxidant effects. Among the studied samples, the infusion had the highest total phenolic content (0.0295 +/- 0.0002 mg GAE/mg extract). According to cytotoxicity results, n-hexane extract had strong cytotoxic effects against PC-3 and NIH/3T3 cell line with IC50 values of 330.40 mu g/mL and 340.85 mu g/mL, respectively. In the antibacterial activity screening, the ethyl acetate extract showed higher activity against Enterecocus facecalis, Klebsiella pneumoniae, Proteus mirabilis with 625 mu g/mL MIC value. According to the research carried out, it would seem that this is the first study on screening biological activities of extracts from Scutellaria sibthorpii. These findings indicate that these endemic species from Cyprus could be used in phytopharmaceutical preparation.en_US
dc.identifier.citationToplan, G. G., Taskin, T., Oztas, E., Hacioglu, M., Tufan, S., Sariyar, G., Mat, A. (2022). Antioxidant, antimicrobial, anti-urease and cytotoxic activities of various extracts from Scutellaria sibthorpii endemic to Cyprus, 21(3), 522-530.en_US
dc.identifier.endpage530en_US
dc.identifier.issn0972-5938en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage522en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3127
dc.identifier.volume21en_US
dc.identifier.wosWOS:000838325200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGülsoy Toplan, Gizem
dc.language.isoenen_US
dc.publisherNATL INST SCIENCE COMMUNICATION-NISCAIRen_US
dc.relation.ispartofINDIAN JOURNAL OF TRADITIONAL KNOWLEDGEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectAnti-ureaseen_US
dc.subjectCytotoxic Activityen_US
dc.subjectScutellariaen_US
dc.subjectTraditional Medicineen_US
dc.titleAntioxidant, antimicrobial, anti-urease and cytotoxic activities of various extracts from Scutellaria sibthorpii endemic to Cyprusen_US
dc.typeArticleen_US

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