Clinical comprehensive and experimental assessment of the radioprotective effect of Annona muricata leaf extract to prevent cellular damage in the ileum tissue

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dc.authoridHüseyin Ozan Tekin / 0000-0002-0997-3488en_US
dc.authorscopusidHüseyin Ozan Tekin / 56971130700en_US
dc.authorwosidHüseyin Ozan Tekin / J-9611-2016
dc.contributor.authorElmas, Özlem
dc.contributor.authorŞahin, Havva Hande Keser
dc.contributor.authorKeskin, Emrah
dc.contributor.authorGüven, Berrak
dc.contributor.authorUslu Erdemir, Rabiye
dc.contributor.authorAlmisned, Ghada
dc.contributor.authorZakaly, Hesham M. H.
dc.contributor.authorEne, Antoaneta
dc.contributor.authorTekin, Hüseyin Ozan
dc.date.accessioned2022-11-04T05:16:57Z
dc.date.available2022-11-04T05:16:57Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümüen_US
dc.description.abstractWe report the radioprotective attitude of Annona muricata (AM) leaf extract as antioxidant material to prevent cellular damage in the ileum tissue. The protective effects of an ethyl acetate extract of AM leaves are comprehensively investigated against radiation-induced ileal damage in numerous rats. Thirty-two adult female rats were separated into 4 groups (3 intervention groups and 1 control) as follows: controls received 0.01 mL/kg distilled water, the AM group received 300 mg/kg AM leaf extract, the ionizing radiation (IR) group received a single dose of whole body radiation (8.3 Gy) after 0.01 mL/kg saline treatment, and the AM + IR group received 300 mg/kg AM leaf extract treatment and were subjected to whole body radiation (8.3 Gy) 1 h after the last gavage. All treatments are administered by oral gavage once a day for 9 days. At the end of the experiment, biochemical total oxidant status (TOS, interleukin-6, and caspase) and histological examinations are performed on blood samples as well as ileum tissue. TOS levels are found to be significantly high in rats, which received irradiation, and those in the AM group when compared to controls. These findings suggest that AM has radioprotective effects on ileum tissue, likely because of its antioxidative properties. The findings of this research may contribute to the minimizing of major side effects induced by excessive radiation exposure in patients undergoing radiotherapy and may serve as a significant impetus for further assessments. However, future studies are highly recommended to confirm safety and to determine extraction technique and dosage before human use can be considered.en_US
dc.identifier.citationElmas, O., Sahin, H. H. K., Keskin, E., Guven, B., Uslu Erdemir, R., Almisned, G., . . . Tekin, H. O. (2022). Clinical comprehensive and experimental assessment of the radioprotective effect of annona muricata leaf extract to prevent cellular damage in the ileum tissue. Open Chemistry, 20(1), 929-938. doi:10.1515/chem-2022-0205en_US
dc.identifier.doi10.1515/chem-2022-0205en_US
dc.identifier.endpage938en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85139209329en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage929en_US
dc.identifier.urihttps://doi.org/10.1515/chem-2022-0205
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3219
dc.identifier.volume20en_US
dc.identifier.wosWOS:000858415500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTekin, Hüseyin Ozan
dc.language.isoenen_US
dc.publisherDe Gruyter Open Ltden_US
dc.relation.ispartofOpen Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnnona Muricataen_US
dc.subjectApoptosisen_US
dc.subjectIrradiationen_US
dc.subjectOxidative Stressen_US
dc.subjectRadioprotectiveen_US
dc.titleClinical comprehensive and experimental assessment of the radioprotective effect of Annona muricata leaf extract to prevent cellular damage in the ileum tissueen_US
dc.typeArticleen_US

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