Effects of agmatine on cognitive functions during vascular dementia in biological aging through eNOS and BDNF expression

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dc.authoridYusuf Sarıoğlu / 0000-0002-9227-365Xen_US
dc.authorscopusidYusuf Sarıoğlu / 7003713314
dc.authorwosidYusuf Sarıoğlu / DRN-8389-2022
dc.contributor.authorBağcı, Bülent
dc.contributor.authorUtkan, Tijen
dc.contributor.authorYazir, Yusufhan
dc.contributor.authorAricioglu, Feyza
dc.contributor.authorOzturk, Gokce Sevim
dc.contributor.authorSarıoğlu, Yusuf
dc.date.accessioned2020-08-30T20:08:19Z
dc.date.available2020-08-30T20:08:19Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Biological aging has been recognized to cause impairment of memory and the development of vascular dementia. Based on our previous work, agmatine has been shown to have a beneficial effect and might have therapeutic potential on cognitive functions, including learning and memory. The aim of the present study was to examine the possible effect of agmatine on biological aging-induced vascular endothelial dysfunction and associated dementia in rats. Methods: We used three different age groups (4-month-olds, 18-month-olds and 24-montholds; n = 12 in each group) of control and agmatine-treated rats. Control animals received physiological saline for 8 weeks. Agmatine sulfate (40 mg/kg, twice daily) was given to the agmatine groups orally for 8 weeks. Herein, we investigated the effects of agmatine on systolic blood pressure (SBP), nitric oxide (NO)-mediated endothelium-dependent and - independent vasorelaxant responses in thoracic aorta, cognitive performance (passive avoidance test; PAT, and Morris water maze test; MWMT), endothelial nitric oxide synthase (eNOS) expression and both hippocampal and amygdaloid brain-derived neurotrophic factor (BDNF) expression in aged rats. Results: We found cognitive decline, endothelial dysfunction and reduced eNOS and BDNF expression in aged rats. All these changes may result from aging-induced vascular dementia. We also found that chronic treatment with agmatine may improve amygdala-dependent emotional and spatial learning and memorial performance, and endothelial function, and may regulate eNOS and BDNF protein expression in aged rats. Conclusion: Results of the current study point out that chronic agmatine treatment may prevent endothelial dysfunction associated with vascular dementia through eNOS and BDNF expression in aged rats.en_US
dc.description.sponsorshipGazi Universitesi Research Fund [01/2010-80]en_US
dc.description.sponsorshipThis study was supported by the Grant from the Gazi Universitesi Research Fund [project number: 01/2010-80] and presented at the 27th European College of Neuropsychopharmacology Congress, 18- 21 October 2014, Berlin, Germany. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.citationBağcı, B., Utkan, T., Yazir, Y., Aricioglu, F., Öztürk, G. S., & Sarioglu, Y. (2017). Effects of agmatine on cognitive functions during vascular dementia in biological aging through eNOS and BDNF expression. Psychiatry and Clinical Psychopharmacology, 27(2), 106-115.en_US
dc.identifier.doi10.1080/24750573.2017.1309090en_US
dc.identifier.endpage115en_US
dc.identifier.issn2475-0573en_US
dc.identifier.issn2475-0581en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85042423265en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage106en_US
dc.identifier.urihttps://doi.org/10.1080/24750573.2017.1309090
dc.identifier.urihttps://hdl.handle.net/20.500.12713/920
dc.identifier.volume27en_US
dc.identifier.wosWOS:000403941900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorSarıoğlu, Yusufen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPsychiatry and Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgingen_US
dc.subjectAgmatineen_US
dc.subjectPassive Avoidanceen_US
dc.subjectMorris Water Mazeen_US
dc.subjectVascular Dementiaen_US
dc.titleEffects of agmatine on cognitive functions during vascular dementia in biological aging through eNOS and BDNF expressionen_US
dc.typeArticleen_US

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