Clinical and Cytokine Profile of Children With COVID-19: A Report From Turkey

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dc.authoridUNSAL, VELİD/0000-0003-1415-0563
dc.authorwosidUNSAL, VELİD/A-6189-2019
dc.contributor.authorDalkiran, Tahir
dc.contributor.authorKara, Emine M.
dc.contributor.authorUnsal, Velid
dc.contributor.authorYurttutan, Sadik
dc.contributor.authorIpek, Sevcan
dc.contributor.authorDagoglu, Besra
dc.contributor.authorKandur, Yasal
dc.date.accessioned2024-05-19T14:46:38Z
dc.date.available2024-05-19T14:46:38Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground We aimed to analyze the expression of infection-related biomarkers and inflammatory cytokines in laboratory-confirmed cases and compare the differences between clinically severe and non-severe ones.Method We randomly selected 35 patients who were hospitalized with the diagnosis of coronavirus disease 2019 (COVID-19). Blood serum was obtained at the time of admission to the hospital, on the third to the fifth day, and at the time of discharge.Result The median age of our patients was 56.5 +/- 69.7 months (range: 1-205 months). The mean pro-B-type natriuretic peptide (pro-BNP) was significantly higher at the time of admission than on the third to the fifth day of illness. The mean pro-B-type natriuretic peptide levels at three time points were significantly higher in patients with severe cases than in mild-moderate cases. However, there was no significant difference between the clinical severity with regard to the cytokine levels at disease onset and recovery.Conclusion In the study, it was shown that cytokines play an important role in the pathogenesis of COVID-19. Therefore, it may be beneficial to use agents such as tocilizumab in the treatment.en_US
dc.identifier.doi10.7759/cureus.37139
dc.identifier.issn2168-8184
dc.identifier.issue4en_US
dc.identifier.pmid37034144en_US
dc.identifier.urihttps://doi.org10.7759/cureus.37139
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5562
dc.identifier.volume15en_US
dc.identifier.wosWOS:000975273000030en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectSevere Casesen_US
dc.subjectPediatric Patienten_US
dc.subjectPro-Bnpen_US
dc.subjectInflammatory Cytokinesen_US
dc.subjectCovid-19en_US
dc.titleClinical and Cytokine Profile of Children With COVID-19: A Report From Turkeyen_US
dc.typeArticleen_US

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