Pd(II) and Pt(II) saccharinate complexes with two phosphine derivatives: Synthesis, anticancer and antiangiogenic activities

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dc.authoridYilmaz, Veysel Turan/0000-0002-2849-3332
dc.authoridIcsel, Ceyda/0000-0002-2717-2430
dc.authoridAygun, Muhittin/0000-0001-9670-9062
dc.authoridErkisa Genel, Merve/0000-0002-3127-742X
dc.authoridAKAR, Okan/0000-0001-8687-2034
dc.authoridUlukaya, Engin/0000-0003-4875-5472
dc.authorwosidYilmaz, Veysel Turan/L-7238-2018
dc.authorwosidAygun, Muhittin/E-9590-2011
dc.contributor.authorIcsel, Ceyda
dc.contributor.authorYilmaz, Veysel T.
dc.contributor.authorAygun, Muhittin
dc.contributor.authorErkisa, Merve
dc.contributor.authorUlukaya, Engin
dc.contributor.authorAkar, R. Okan
dc.date.accessioned2024-05-19T14:39:02Z
dc.date.available2024-05-19T14:39:02Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAs clinically used anticancer Pt(II) drugs have severe side effects, there is a growing interest for new metal complexes with great potential for cancer therapy. The current work aimed to prepare and characterize new Pd(II) and Pt(II) saccharinate (sac) complexes bearing pyridyl- and benzyldiphenylphosphines (PPh2Py and PPh2Bz, respectively), cis-[Pd(sac)2(PPh2Py)2] (1), cis-[PtCl(sac)(PPh2Py)2]center dot 0.5DMF (2), cis-[Pd(sac)2(PPh2Bz)2]center dot DMF (3) and trans-[PtCl(sac)(PPh2Bz)2] (4) as promising anticancer and antiangiogenic drugs. The anticancer activity of the complexes was screened against seven cancer cell lines including HCT116 (colon), HepG2 (liver), MDA-MB-231 (breast), PANC-1 (pancreatic), A549 (lung), C6 (glioma), DU145 (prostate) and normal human lung epithelial cells (BEAS-2B). 1 and 2 did not show biological activity below 20 mu M at 48 h, whereas 3 and 4 displayed significant cytotoxic effect on the cancer cells. 4 was the most potent complex (IC50 = 2.2-12.1 mu M) and displayed much greater cytotoxicity than cisplatin in all the cancer cell lines. 4 caused apoptosis in HCT116 cells as evidenced by annexin V positivity and caspase 3/7 activity assays. Furthermore, the inhibition of antiapoptotic Bcl-2 proteins by the complex suggested the intrinsic apoptosis. In addition, 4 greatly enhanced generation of intracellular reactive oxygen species (ROS) and consequently caused remarkable DNA double-strand breaks in HCT116 cells. Moreover, the chick chorioallantoic membrane (CAM) assay was used to evaluate antiangiogenic potential of 4. The complex effectively inhibited angiogenesis at a dose of 50 ng, suggesting it as a promising multi-targeted agent for antiangiogenic cancer treatment. A trans-configured Pt(II) saccharinate complex bearing benzyldiphenylphosphine inhibits both growth of human colorectal carcinoma cells (HCT116) and angiogenesis, acting as a multifunctional anticancer and antiangiogenic agent. imageen_US
dc.identifier.doi10.1002/aoc.7433
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85186854479en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1002/aoc.7433
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4681
dc.identifier.volume38en_US
dc.identifier.wosWOS:001178627600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofApplied Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAntiangiogenicsen_US
dc.subjectAnticancer Activityen_US
dc.subjectCell Apoptosisen_US
dc.subjectPalladium(Ii) And Platinum(Ii) Complexesen_US
dc.subjectX-Ray Structuresen_US
dc.titlePd(II) and Pt(II) saccharinate complexes with two phosphine derivatives: Synthesis, anticancer and antiangiogenic activitiesen_US
dc.typeArticleen_US

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