Antimicrobial Activity of Novel Deep Eutectic Solvents

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dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridKhan, Amir Sada/0000-0002-9519-595X
dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridKhamis, Mustafa/0000-0002-2196-0911
dc.authoridAlfahemi, Hasan/0000-0003-0017-4337
dc.authoridAkbar, Noor/0000-0002-8114-1969
dc.authoridAlharbi, Ahmad M./0000-0002-9512-1985
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.authorwosidKhan, Amir Sada/Q-8429-2019
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.contributor.authorAkbar, Noor
dc.contributor.authorKhan, Naveed Ahmed
dc.contributor.authorIbrahim, Taleb
dc.contributor.authorKhamis, Mustafa
dc.contributor.authorKhan, Amir Sada
dc.contributor.authorAlharbi, Ahmad M.
dc.contributor.authorAlfahemi, Hasan
dc.date.accessioned2024-05-19T14:39:03Z
dc.date.available2024-05-19T14:39:03Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractHerein, we utilized several deep eutectic solvents (DES) that were based on hydrogen donors and hydrogen acceptors for their antibacterial application. These DES were tested for their bactericidal activities against Gram-positive (Streptococcus pyogenes, Bacillus cereus, Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus) and Gram-negative (Escherichia coli K1, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Serratia marcescens) bacteria. Using lactate dehydrogenase assays, DES were evaluated for their cytopathic effects towards human cells. Results from antibacterial tests revealed that DES prepared from the combination of methyl-trioctylammonium chloride and glycerol (DES-4) and DES prepared form methyl-trioctylammonium chloride and fructose (DES-11) at a 2 mu L dose showed broad-spectrum antibacterial behavior and had the highest bactericidal activity. Moreover, DES-4 showed 40% and 68% antibacterial activity against P. aeruginosa and E. coli K1, respectively. Similarly, DES-11 eliminated 65% and 61% E. coli K1 and P. aeruginosa, respectively. Among Gram-positive bacteria, DES-4 showed important antibacterial activity, inhibiting 75% of B. cereus and 51% of S. pneumoniae. Likewise, DES-11 depicted 70% B. cereus and 50% S. pneumoniae bactericidal effects. Finally, the DES showed limited cytotoxic properties against human cell lines with the exception of the DES prepared from Methyltrioctylammonium chloride and Citric acid (DES-10), which had 88% cytotoxic effects. These findings suggest that DES depict potent antibacterial efficacies and cause minimal damage to human cells. It can be concluded that the selected DES in this study could be utilized as valuable and novel antibacterial drugs against bacterial infections. In future work, the mechanisms for bactericides and the cytotoxicity effects of these DES will be investigated.en_US
dc.identifier.doi10.3390/scipharm91010009
dc.identifier.issn2218-0532
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85151087918en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.3390/scipharm91010009
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4685
dc.identifier.volume91en_US
dc.identifier.wosWOS:000956819300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofScientia Pharmaceuticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAntibiotic Resistanceen_US
dc.subjectMulti-Drug Resistanceen_US
dc.subjectDeep Eutectic Solventsen_US
dc.subjectAntibacterialen_US
dc.subjectCytotoxicityen_US
dc.titleAntimicrobial Activity of Novel Deep Eutectic Solventsen_US
dc.typeArticleen_US

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