Performing the comparative analysis to understand the functional roles of genes in different pathways of cardiomyopathy disease

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dc.authoridDuygu Koyuncu Irmak / 0000-0002-3277-5535en_US
dc.authoridAslı Yenenler-Kutlu / 0000-0002-9169-388X
dc.authorscopusidDuygu Koyuncu Irmak / 57219539042en_US
dc.authorscopusidAslı Yenenler-Kutlu / 57190336603en_US
dc.authorwosidAslı Yenenler-Kutlu / AGG-7405-2022
dc.contributor.authorAtak, Evren
dc.contributor.authorKaraoğlu, Dilara
dc.contributor.authorSerttürk, Seda
dc.contributor.authorKoyuncu Irmak, Duygu
dc.contributor.authorYenenler-Kutlu, Aslı
dc.date.accessioned2021-09-20T10:11:25Z
dc.date.available2021-09-20T10:11:25Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractPersonalized medicine is one of the popular approaches in biological sciences. Due to the great attention in personalized medicine, there exists a need for health decision algorithms developed through high-level pro-gramming languages that already compromised the statistical analyses and numerical computations. Here, we present a tool that enables us to facilitate making research in the PubMed database by classifying the scientific literature from the published abstracts and then performed the comparative analysis to highlight the importance of gene-variant relationships in the decision steps. After retrieving related genes from literature, we performed pathway analysis with them by using computer-based tools to differentiate these sub-pathways in cardiomy-opathy disease that are listed as hypertrophic, dilated, and arrhythmogenic right ventricular cardiomyopathy. Then, the pathogenic variants existing in these genes at each sub-pathway are retrieved, and the mechanistic interpretation about them has been gained to explain more about the differences in genes’ mode of action. Lastly, the need of structure-based studies to explain the etiology of the disease has been emphasized by providing the protein structures of related genes as a guide. This study presents the importance of combining the text-mining approach with the bioinformatics tool in effective manner both for catching up with the updated literature and for revealing newly identified genes or pathways.en_US
dc.identifier.citationAtak, E., Karaoğlu, D., Serttürk, S., Irmak, D. K., & Yenenler-Kutlu, A. (2021). Performing the comparative analysis to understand the functional roles of genes in different pathways of cardiomyopathy disease. Meta Gene, 100975.en_US
dc.identifier.doi10.1016/j.mgene.2021.100975en_US
dc.identifier.endpage9en_US
dc.identifier.issn2214-5400en_US
dc.identifier.scopus2-s2.0-85114845548en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.mgene.2021.100975
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2094
dc.identifier.volume30en_US
dc.identifier.wosWOS:000707187800006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKoyuncu Irmak, Duygu
dc.institutionauthorYenenler-Kutlu, Aslı
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMeta Geneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiomyopathyen_US
dc.subjectComparative Analysisen_US
dc.subjectGene-protein Informationen_US
dc.subjectPersonalized Medicineen_US
dc.subjectText-mining Approachen_US
dc.titlePerforming the comparative analysis to understand the functional roles of genes in different pathways of cardiomyopathy diseaseen_US
dc.typeArticleen_US

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