Synergistic enhancement of osteogenesis: silica nanoparticles and proanthocyanidin on bioinspired nanofibrous scaffolds for craniofacial bone regeneration

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / GSA-3718-2022
dc.contributor.authorGalefi, Atena
dc.contributor.authorHosseini, Saadi
dc.contributor.authorAlipour, Atefeh
dc.contributor.authorBanaeyan, Rezvaneh
dc.contributor.authorFarrokhi, Naser
dc.contributor.authorAmanzadeh, Amir
dc.contributor.authorWang, Peng-Yuan
dc.contributor.authorZarrabi, Ali
dc.contributor.authorShahsavarani, Hosein
dc.date.accessioned2025-04-16T19:52:49Z
dc.date.available2025-04-16T19:52:49Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractThe reconstruction of craniofacial bone defects is a significant challenge in regenerative medicine due to the limitations of standard grafts. In this study, we developed innovative, multifunctional, nanostructured scaffolds derived from Phlomis Monocephala leaves to address this issue. These fibrous cellulose scaffolds were coated with Grape Seed Proanthocyanidin Extract and Silica Nanoparticles, individually and in combination, to enhance their properties for bone tissue engineering applications. The scaffolds were meticulously evaluated for their morphology, chemical composition, swelling behavior, protein adsorption, hydrophilicity, porosity, and their ability to support cell survival, proliferation, and differentiation into bone cells. The scaffolds functionalized with both Grape Seed Proanthocyanidin Extract and Silica Nanoparticles exhibited the most favorable properties, significantly promoting the differentiation of human bone marrow mesenchymal stem cells into osteogenic cells. This was evidenced by increased alkaline phosphatase activity, matrix mineralization, collagen formation, and the expression of genes related to bone formation. Additionally, these nanostructured scaffolds demonstrated superior antibacterial activity against both Gram-positive and Gram-negative bacteria compared to uncoated scaffolds. In vivo biocompatibility assessments revealed that the Grape Seed Proanthocyanidin Extract and Silica Nanoparticles-coated scaffolds performed excellently in terms of re-epithelialization, vascularization, and reducing inflammation, showcasing their potential for future clinical applications. Our findings highlight the immense potential of these nanostructured scaffolds as biocompatible materials for treating bone tissue defects, offering a novel and effective approach in the field of nanotechnology and regenerative medicine. © Qatar University and Springer Nature Switzerland AG 2024.
dc.description.sponsorshipThis research received partial support from the Center for International Scientific Studies and Collaboration (CISSC) of Ministry of Science, Research and Technology of Iran., Grant No. 4010221 to M.J and from Shahid Beheshti Uni Grant No. 1402 to HS.
dc.identifier.citationGalefi, A., Hosseini, S., Alipour, A., Banaeyan, R., Farrokhi, N., Amanzadeh, A., ... & Jahanfar, M. (2024). Synergistic enhancement of osteogenesis: silica nanoparticles and proanthocyanidin on bioinspired nanofibrous scaffolds for craniofacial bone regeneration. Emergent Materials, 1-24.
dc.identifier.doi10.1007/s42247-024-00909-5
dc.identifier.issn25225731
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1007/s42247-024-00909-5
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6058
dc.identifier.wosWOS:001358571600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofEmergent Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBioinspired Scaffolds
dc.subjectBone Tissue Engineering
dc.subjectNanofibers
dc.subjectOsteogenic Differentiation
dc.subjectProanthocyanidin
dc.subjectSilica Nanoparticles
dc.titleSynergistic enhancement of osteogenesis: silica nanoparticles and proanthocyanidin on bioinspired nanofibrous scaffolds for craniofacial bone regeneration
dc.typeArticle

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