Hyperbranched polymer-based nanoparticle drug delivery platform for the nucleus-targeting in cancer therapy

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dc.authoridYucel, Oguz/0000-0003-1389-2899
dc.authoridBAL OZTURK, AYCA/0000-0002-6502-528X
dc.authoridEROL, TUGBA/0000-0003-2835-0291
dc.authoridEmik, Serkan/0000-0002-6005-9704
dc.authoridYildirim, Zeynep Puren/0000-0002-9626-1605
dc.authorwosidYucel, Oguz/AAH-2304-2019
dc.authorwosidBAL OZTURK, AYCA/M-4472-2018
dc.authorwosidEmik, Serkan/C-9239-2019
dc.contributor.authorBal-Ozturk, Ayca
dc.contributor.authorTietilu, Sherif Domingo
dc.contributor.authorYuecel, Oguz
dc.contributor.authorErol, Tugba
dc.contributor.authorAkguner, Zeynep Puren
dc.contributor.authorDarici, Hakan
dc.contributor.authorAlarcin, Emine
dc.date.accessioned2024-05-19T14:41:36Z
dc.date.available2024-05-19T14:41:36Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractHyperbranched polymers (HPB) are drawing attention as one of the drug delivery platforms that can encapsulate drugs owing to the internal voids in their three-dimensional construct. It is feasible to develop HBP-based nano -sized drug delivery platforms and improve the efficacy of cancer treatment due to its potential properties. In particular, the contribution of targeted drug delivery systems that can target malignant tissues in the treatment processes is undeniable. For this purpose, modifying an HBP-based nanoparticle delivery system with a targeting molecule is vital. In this study, we synthesized folic acid-modified HBP-based nanoparticles and their physical (DLS, zeta potential) and chemical (FTIR, NMR) characterizations were performed, and finally 5-Fluorouracil (5-FU) was loaded as a model active agent. The release properties (UV-VIS) and release kinetic models of 5-FU-loaded folic acid-modified nanoparticles were investigated in different pHs. In vitro cellular activities (MTT, cellular uptake) and targeting properties to the folate receptor (FR) were determined by flow cytometry on HeLa (FR, +) and L929 (FR,-) cells. According to all the results, folic acid-modified HBP-based nanoparticles were efficiently transported to the cell nucleus in the targeted FR + cells, and internalization of nanoparticles in HeLa cells is similar to 2.5 times higher than L929 cells. All results suggest that folic acid modification to the nanoparticles is critical in folate receptor-positive cancer treatment.en_US
dc.description.sponsorshipResearch Fund of Istanbul University-Cerrahpasa [117Z732, FYL-2020-34,534]; Scientific and Technological Research Council of Turkey (TUBITAK)en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) and Research Fund of Istanbul University-Cerrahpasa (Grant numbers 117Z732 and FYL-2020-34,534) .en_US
dc.identifier.doi10.1016/j.jddst.2023.104195
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85147119573en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.jddst.2023.104195
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5132
dc.identifier.volume81en_US
dc.identifier.wosWOS:000927560400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectFolic Aciden_US
dc.subjectTargeted Drug Deliveryen_US
dc.subjectCanceren_US
dc.subjectHyperbranched Polymeren_US
dc.subject5-Fluorouracilen_US
dc.titleHyperbranched polymer-based nanoparticle drug delivery platform for the nucleus-targeting in cancer therapyen_US
dc.typeArticleen_US

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