Diagnostic Role of Opsonic Activity in Acinetobacter baumannii Ventilator-Associated Pneumonia

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dc.contributor.authorKarakullukçu, A.
dc.contributor.authorAkker, M.
dc.contributor.authorKuşkucu, M.A.
dc.contributor.authorDikmen, Y.
dc.contributor.authorAygün, G.
dc.date.accessioned2024-05-19T14:33:15Z
dc.date.available2024-05-19T14:33:15Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIn this study, we investigated the diagnostic value of opsonic activity against Acinetobacter baumannii in Ventilator-Associated Pneumonia (VAP) among 50 patients, compared to 102 negative and positive controls. Out of the 50 patients, only 33 (66 %) were diagnosed with VAP using the Clinical Pulmonary Infection Score (CPIS). The opsonic activity assay demonstrated three key findings: (i) 95 % sensitivity and 91.7 % specificity, with a Receiver Operating Characteristic (ROC) area of 0.976 for distinguishing A. baumannii culture positives from negatives; (ii) 95 % sensitivity and 78.7 % specificity, with a 0.915 ROC area, in differentiating VAP/blood culture positive patients from colonized/negative groups; (iii) An ROC area of 0.553 for VAP and colonization, as identified by CPIS alone, indicating an indeterminate threshold. These results highlight that CPIS, microbiological, and clinical evaluations were not correlated, suggesting that opsonic activity against A. baumannii could be a potential VAP diagnostic tool, with the need for large-scale validations. © 2024en_US
dc.description.sponsorship40105en_US
dc.description.sponsorshipThis work was supported by the Istanbul University Scientific Research Projects in Turkey [Project Number: 40105 to Asiye Karakulluk\u00E7u ].en_US
dc.identifier.doi10.1016/j.diagmicrobio.2024.116262
dc.identifier.issn0732-8893
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85189972872en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.diagmicrobio.2024.116262
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4160
dc.identifier.volume109en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAcinetobacter Baumanniien_US
dc.subjectClinical Pulmonary İnfection Score (Cpıs)en_US
dc.subjectOpsonic Activityen_US
dc.subjectRapid Diagnostic Techniquesen_US
dc.subjectVentilator-Associated Pneumonia (Vap)en_US
dc.titleDiagnostic Role of Opsonic Activity in Acinetobacter baumannii Ventilator-Associated Pneumoniaen_US
dc.typeArticleen_US

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