Alginate-based nanocomposite incorporating chitosan nanoparticles: A dual-drug delivery system for infection control and wound regeneration

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorMousavi, Seyed Javad
dc.contributor.authorHeydari, Parisa
dc.contributor.authorJavaherchi, Pouya
dc.contributor.authorKharazi, Anoushe Zargar
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2025-04-17T08:34:18Z
dc.date.available2025-04-17T08:34:18Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractIn this study, a hydrogel-based nanocomposite was fabricated as a novel wound dressing and drug delivery system. Initially, insulin-loaded chitosan nanoparticles (CSNP-INS) were produced using the ionic gelation technique. Subsequently, the CSNP-INS were introduced into ciprofloxacin-loaded sodium alginate (SA-Cip) hydrogel at two different concentrations (0.5 % and 1 % w/v), followed by crosslinking with CaCl2 after freezedrying to enhance its physical and biological properties. The CSNP-INS nanoparticles had an average size of 173.6 f 1.76 nm and effectively encapsulated 70 % of the INS. Physicochemical characterization revealed that SA-Cip/1%CSNP-INS has significant swelling (2996 f 31.55 %) and high hydrophilicity (16.94 f 0.99 degrees), along with slow degradation due to the electrostatic interaction between CSNP and SA hydrogel (80 % weight loss after 14 days). Moreover, the mechanical properties were enhanced due to the higher concentration of CSNP (83 f 1.9 kPa), with a Young's modulus of 83 f 1.9 kPa. The release profile of INS after incorporation of CSNP-INS into the hydrogel was slower and more sustained. On the other hand, Cip showed a burst release (100 % within 6 h). In vitro assays of the fabricated hydrogels on fibroblastic cells demonstrated high cell viability, enhanced cell migration, and complete in-vitro wound closure (100 % within 24 h). Further analysis of the inflammatory response of hydrogels revealed a significant impact on modulating inflammation markers including a decrease in TNF-alpha and an increase in TGF-beta. Cip and INS facilitate different wound-healing stages, ensuring efficient and accelerated wound healing. This study underscores the potential of the developed hydrogel as groundbreaking wound dressing, offering enhanced wound healing capabilities through an innovative mechanism of controlled and sustained drug release.
dc.description.sponsorshipIsfahan University of Medical Sciences
dc.identifier.citationMousavi, S. J., Heydari, P., Javaherchi, P., Kharazi, A. Z., & Zarrabi, A. (2025). Alginate-based Nanocomposite Incorporating Chitosan Nanoparticles: A Dual-Drug Delivery System for Infection Control and Wound Regeneration. Journal of Drug Delivery Science and Technology, 106755.
dc.identifier.doi10.1016/j.jddst.2025.106755
dc.identifier.endpage10
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85219110187
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.jddst.2025.106755
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6169
dc.identifier.volume107
dc.identifier.wosWOS:001440875500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherEditions de sante
dc.relation.ispartofJournal of drug delivery science and technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCiprofloxacin
dc.subjectCS Nanoparticles
dc.subjectInsulin
dc.subjectNanocomposite Film
dc.subjectSodium Alginate Hydrogel
dc.titleAlginate-based nanocomposite incorporating chitosan nanoparticles: A dual-drug delivery system for infection control and wound regeneration
dc.typeArticle

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