Antiviral Properties of 5-Sulfamoyl-1H-Indole-Linked Spirothiazolidinone Derivatives: A Study on Human Parainfluenza Virus-2

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dc.authoridAkdemir, Atilla/0000-0001-8416-0471
dc.authoridTrawally, Muhammed/0000-0002-0041-4612
dc.authorwosidAkdemir, Atilla/G-2595-2015
dc.contributor.authorTrawally, Muhammed
dc.contributor.authorYilmaz, Fatima Nur
dc.contributor.authorOzbek Celik, Berna
dc.contributor.authorAkdemir, Atilla
dc.contributor.authorGuzel Akdemir, Ozlen
dc.date.accessioned2024-05-19T14:46:09Z
dc.date.available2024-05-19T14:46:09Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractHuman parainfluenza viruses (HPIVs) are responsible for a wide range of respiratory infections in humans, particularly in children, the elderly, and immunocompromised individuals. This paper presents a study regarding the antiviral activity of a series of 3-phenyl-5-sulfamoyl-N-(7/8/9-(non)substituted-3-oxo-1-thia-4- azaspiro[4.4]non/[4.5]dec-4-yl)-1H-indole-2-carboxamide derivatives against HPIV-2. Our findings suggest the compounds displayed low potency against HPIV-2. Compounds 4 and 8 exhibited the most potent antiviral effects with inhibition of 95.46 and 90.90 % at 10 mg/mL, respectively. Molecular modeling studies were conducted on hemagglutinin-neuraminidase, a crucial druggable target for HPIV, to predict the binding modes of the compounds.en_US
dc.description.sponsorshipIstanbul University Scientific Research Projects [T-15108]en_US
dc.description.sponsorshipThis research was funded by Istanbul University Scientific Research Projects under project Number: T-15108.en_US
dc.identifier.doi10.29228/jrp.689
dc.identifier.endpage224en_US
dc.identifier.issn2630-6344
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85185505017en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org10.29228/jrp.689
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5456
dc.identifier.volume28en_US
dc.identifier.wosWOS:001167297700013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectParainfluenza Virusen_US
dc.subjectHpiv-2en_US
dc.subjectIndoleen_US
dc.subjectThiazolidinoneen_US
dc.subjectHemagglutinin-Neuraminidaseen_US
dc.subjectMolecular Dockingen_US
dc.titleAntiviral Properties of 5-Sulfamoyl-1H-Indole-Linked Spirothiazolidinone Derivatives: A Study on Human Parainfluenza Virus-2en_US
dc.typeArticleen_US

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