Eggshell integrated GelMA/CSMA/HyMA hybrid hydrogels for cell therapy/tissue engineering

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dc.authoridyüce, elif/0000-0002-1444-0934
dc.authoridBAL OZTURK, AYCA/0000-0002-6502-528X
dc.authorwosidyüce, elif/ABH-5529-2020
dc.authorwosidBAL OZTURK, AYCA/M-4472-2018
dc.contributor.authorYuce-Erarslan, Elif
dc.contributor.authorIzbudak, Burcin
dc.contributor.authorKizilkurtlu, Ahmet Akif
dc.contributor.authorTopal, Merve
dc.contributor.authorAkpek, Ali
dc.contributor.authorBal-Ozturk, Ayca
dc.date.accessioned2024-05-19T14:41:08Z
dc.date.available2024-05-19T14:41:08Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe use of biocompatible materials with improved behaviors for potential applications in the area of tissue engineering has increased as the developments in biomaterials have increased in recent years. Current approaches concentrate on hybrid combinations of synthetic and natural polymers. In this context, obtaining porous scaffolds with good mechanical properties is still challenging. Herein, a hybrid tissue scaffold consisting of methacrylated gelatin (GelMA), methacrylated chondroitin sulfate (CSMA), methacrylated hyaluronic acid (HyMA) and eggshell particles with enhanced pore morphology and mechanical property was fabricated by photo-polymerization. The effect of different amounts of eggshell particles on the behaviors of hybrid hydrogel scaffolds was investigated. It was determined by scanning electron microscope analysis (SEM) that the particles were well-dispersed and triggered the formation of an interconnected porous structure in the hybrid tissue scaffold containing 10% by weight of eggshell particles. It was concluded that the mechanical behaviors of the hybrid tissue scaffold containing 10% by weight of eggshell particles improved by 47% compared to the neat hydrogel scaffold. There were no toxic effects of eggshell particles-integrated scaffolds against osteoblast cells. In addition, cells successfully adhered onto the scaffolds and proliferated. Consequently, GelMA/CSMA/HyMA scaffolds containing 10% eggshell particles were found to be biocompatible and suitable for cell therapy and tissue engineering applications.en_US
dc.description.sponsorshipTuerkiye Bilimsel ve Teknolojik Arastirma Kurumu [118S549]; Yildiz Technical University Scientific Research Projects Coordination [FCD-2021-4687]en_US
dc.description.sponsorshipTuerkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 118S549; Yildiz Technical University Scientific Research Projects Coordination, Grant/Award Number: FCD-2021-4687en_US
dc.identifier.doi10.1002/app.54310
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue34en_US
dc.identifier.scopus2-s2.0-85163210410en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1002/app.54310
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5068
dc.identifier.volume140en_US
dc.identifier.wosWOS:001019188500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Applied Polymer Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectEggshellen_US
dc.subjectMethacrylated Chondroitin Sulfateen_US
dc.subjectMethacrylated Gelatinen_US
dc.subjectMethacrylated Hyaluronic Aciden_US
dc.subjectTissue Engineeringen_US
dc.titleEggshell integrated GelMA/CSMA/HyMA hybrid hydrogels for cell therapy/tissue engineeringen_US
dc.typeArticleen_US

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