The effect of vitamin c in the formulation of pectin/thiolated alginate buccal adhesive patches: in vitro and ex vivo evaluation

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dc.authoridGülşah Torkay / 0000-0002-6803-494Xen_US
dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authorscopusidGülşah Torkay / 57753937500en_US
dc.authorscopusidAyça Bal Öztürk / 57062000100en_US
dc.authorwosidGülşah Torkay / GPU-5169-2022en_US
dc.authorwosidAyça Bal Öztürk / M-4472-2018en_US
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorTorkay, Gülşah
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2022-11-13T19:18:01Z
dc.date.available2022-11-13T19:18:01Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Bölümüen_US
dc.description.abstractThe present study outlines the prospect of a pectin (Pec)/modified alginate (Alg) buccal patch as drug delivery device in the localized treatment of oral cavity diseases. Firstly, Alg was modified with acrylic acid, and thiolated with cystein to enhance its mucoadhesive properties. Then modified Alg was characterized with Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1HNMR) spectroscopy. As a proof of concept, Pec/modified Alg buccal patches were formed via the conventional solvent casting technique. Then the patches were characterized by FTIR and differential scanning calorimetry/thermal gravimetric analysis (DSC/TGA). Vitamin C (Vit C) was used for in vitro drug release assay, and the release amount was 2.10 mg/g polymer in simulated salivary pH 6.8. Ex vivo mucoadhesion assays of Vit C loaded Pec/modified Alg patch did not have a negative effect on the mucoadhesion feature of the material. The cytotoxicity study indicated that Pec/modified Alg buccal patches did not exhibit apparent cytotoxicity against NIH/3T3 cell lines. Notably, it was found that Vit C in the patch formulation has an accelerating effect on wound healing. According to all results, Vit C loaded Pec/modified Alg buccal patch might be a promising candidate for localized buccal drug release systems.en_US
dc.identifier.citationÖzkahraman, B., Torkay, G., Özbaş, Z., & Bal-Öztürk, A. (2022). The effect of vitamin C in the formulation of pectin/thiolated alginate buccal adhesive patches: In vitro and Ex vivo evaluation. International Journal of Adhesion and Adhesives, 103276.en_US
dc.identifier.doi10.1016/j.ijadhadh.2022.103276en_US
dc.identifier.issn0143-7496en_US
dc.identifier.scopus2-s2.0-85139860776en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijadhadh.2022.103276
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3369
dc.identifier.wosWOS:000891850200003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTorkay, Gülşah
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofInternational Journal of Adhesion and Adhesivesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEx Vivoen_US
dc.subjectPectinen_US
dc.subjectThiolated Alginateen_US
dc.subjectWound Healingen_US
dc.titleThe effect of vitamin c in the formulation of pectin/thiolated alginate buccal adhesive patches: in vitro and ex vivo evaluationen_US
dc.typeArticleen_US

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