Promising breakthroughs in amyotrophic lateral sclerosis treatment through nanotechnology's unexplored frontier

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorSojdeh, Soheil
dc.contributor.authorSafarkhani, Moein
dc.contributor.authorDaneshgar, Hossein
dc.contributor.authorAldhaher, Abdullah
dc.contributor.authorHeidari, Golnaz
dc.contributor.authorNazarzadeh Zare, Ehsan
dc.contributor.authorIravani, Siavash
dc.contributor.authorZarrabi, Ali
dc.contributor.authorRabiee, Navid
dc.date.accessioned2025-04-17T11:51:13Z
dc.date.available2025-04-17T11:51:13Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractThis review explores the transformative potential of nanotechnology in the treatment and diagnosis of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder characterized by motor neuron degeneration, muscle weakness, and eventual paralysis. Nanotechnology offers innovative solutions across various domains, including targeted drug delivery, neuroprotection, gene therapy and editing, biomarker detection, advanced imaging techniques, and tissue engineering. By enhancing the precision and efficacy of therapeutic interventions, nanotechnology facilitates key advancements such as crossing the blood-brain barrier, targeting specific cell types, achieving sustained therapeutic release, and enabling combination therapies tailored to the complex pathophysiology of ALS. Despite its immense promise, the clinical translation of these approaches faces challenges, including potential cytotoxicity, biocompatibility, and regulatory compliance, which must be addressed through rigorous research and testing. This review emphasizes the application of nanotechnology in targeted drug delivery and gene therapy/editing for ALS, drawing on the author's prior work with various nanotechnological platforms to illustrate strategies for overcoming similar obstacles in drug and gene delivery. By bridging the gap between cutting-edge technology and clinical application, this article aims to highlight the vital role of nanotechnology in shaping the future of ALS treatment.
dc.identifier.citationSojdeh, S., Safarkhani, M., Daneshgar, H., Aldhaher, A., Heidari, G., Zare, E. N., ... & Rabiee, N. (2024). Promising Breakthroughs in Amyotrophic Lateral Sclerosis Treatment through Nanotechnology's Unexplored Frontier. European Journal of Medicinal Chemistry, 117080.
dc.identifier.doi10.1016/j.ejmech.2024.117080
dc.identifier.endpage13
dc.identifier.issn02235234
dc.identifier.pmid39577228
dc.identifier.scopus2-s2.0-85209586531
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.ejmech.2024.117080
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6235
dc.identifier.volume282
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherElsevier masson s.r.l.
dc.relation.ispartofEuropean journal of medicinal chemistry
dc.relation.publicationcategoryDiÄŸer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmyotrophic Lateral Sclerosis
dc.subjectDrug Delivery
dc.subjectGene Delivery
dc.subjectMotor Neuron Disease
dc.subjectNanotechnology
dc.titlePromising breakthroughs in amyotrophic lateral sclerosis treatment through nanotechnology's unexplored frontier
dc.typeOther

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