Garlic Exosomes Promote Hair Growth Through the Wnt/?-catenin Pathway and Growth Factors

Basit Öğe Kaydı
dc.authorwosidInan yuksel, ESMA/V-9064-2018
dc.contributor.authorYuksel, Esma Inan
dc.contributor.authorCicek, Demet
dc.contributor.authorDemir, Betul
dc.contributor.authorSahin, Kazim
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorOrhan, Cemal
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.date.accessioned2024-05-19T14:50:23Z
dc.date.available2024-05-19T14:50:23Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground Exosomes are membrane-derived nanovesicles produced by cells and play an important role in intercellular communication. Objectives This study aimed to investigate the effects of garlic exosome (GE) on hair growth. Methods Forty-two Sprague-Dawley/Wistar albino rats were randomly divided into six groups: non-shaved control, shaved control, topical control, GE 2 mg, GE 4 mg, and topical GE. At the end of the experiment, the number of hair follicles, follicle diameter, and subcutaneous tissue thicknesses were measured histopathologically. The Wnt-1, beta-catenin, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor-beta 1 (TGF-beta 1), and collagen I levels were measured by the Western Blot method. Results The anagen follicle counts of the GE 2 mg, 4 mg, and topical GE groups were 66.57 +/- 15.49, 105.71 +/- 25.06, and 55.29 +/- 6.72, and were significantly higher than the control groups (p<0.01, p<0.001 and p<0.05, respectively). The follicle diameter of the GE 4 mg group was higher than the others (p<0.05). The Wnt-1, PDGF, VEGF, TGF-beta 1, and collagen I levels of all GE groups, and the beta-catenin levels of the GE 4 mg and topical GE groups were significantly higher than the control groups (p<0.05). Conclusion GE induces hair growth in rats via the Wnt-1, beta-catenin, VEGF, PDGF, and TGF-beta 1 signaling pathways.en_US
dc.identifier.doi10.7759/cureus.42142
dc.identifier.issn2168-8184
dc.identifier.issue7en_US
dc.identifier.pmid37602007en_US
dc.identifier.urihttps://doi.org10.7759/cureus.42142
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5690
dc.identifier.volume15en_US
dc.identifier.wosWOS:001054485200016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectWnt Signaling Pathwayen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectTransforming Growth Factor Betaen_US
dc.subjectHair Follicleen_US
dc.subjectGarlicen_US
dc.subjectExosomeen_US
dc.titleGarlic Exosomes Promote Hair Growth Through the Wnt/?-catenin Pathway and Growth Factorsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu