Phytochemical composition and pharmacological activities of Teucrium polium L. Collected from eastern Turkey

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dc.authoridGizem Gülsoy Toplan / 0000-0002-0544-2532
dc.authorscopusidGizem Gülsoy Toplan / 57192304526
dc.authorwosidGizem Gülsoy Toplan / EYL-0628-2022
dc.contributor.authorGülsoy Toplan, Gizem
dc.contributor.authorGöger, Fatih
dc.contributor.authorTaşkın, Turgut
dc.contributor.authorEcevit-Genç, Gülay
dc.contributor.authorCivaş, Ayşe
dc.contributor.authorİşcan, Gökalp
dc.contributor.authorKürkçüoğlu, Mine
dc.contributor.authorMat, Afife
dc.contributor.authorBaşer, K. Hüsnü Can
dc.date.accessioned2022-03-23T05:54:56Z
dc.date.available2022-03-23T05:54:56Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractTeucrium species that belong to the family Lamiaceae have been traditionally used for their medicinal properties. T. polium is one the most widespread members of the genus for its use in the treatment of several diseases. In this study, the essential oil and phenolic composition of the aerial parts from T. polium were assessed by GC-FID, GC/MS, and LC-MS/MS as well as for its total phenolic content. Several extracts such as n-hexane, chloroform, methanol, and infusion were prepared and their antimicrobial, antioxidant, and also acetylcholinesterase activities were studied. According to GC/MS results, ß -caryophyllene (8.8%), t-cadinol (6.2%), (E)-nerolidol (5%), ? -cadinol (5.4%), and a-pinene (4.7%) were identified as main constituents of the essential oil. LC MS/MS analysis of the infusion and the methanol extract showed the presence of 15 phenolic compounds. Moreover, the total phenolic content of each sample was also determined and the infusion had the highest percentage of phenolics. To evaluate the antioxidant properties, the samples were tested by using DPPH” free radical scavenging, FRAP, and CUPRAC activity methods. The infusion showed the strongest radical scavenging activity, whereas n-hexane and chloroform extracts exhibited considerable reducing power effects. The MIC values for all of the examined microorganisms ranged from 15 to 2000 µg/mL with respect to antimicrobial activities. © TÜBİTAKen_US
dc.identifier.citationGülsoy Toplan, G., Göger, F., Taşkin, T., Ecevit-Genç, G., Civaş, A., Işcan, G., . . . Başer, K. H. C. (2022). Phytochemical composition and pharmacological activities of teucrium polium L. collected from eastern turkey. Turkish Journal of Chemistry, 46(1), 269-282. doi:10.3906/kim-2107-13en_US
dc.identifier.doi10.3906/kim-2107-13en_US
dc.identifier.endpage282en_US
dc.identifier.issn1300-0527en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85126148381en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage269en_US
dc.identifier.urihttps://doi.org/10.3906/kim-2107-13
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2576
dc.identifier.volume46en_US
dc.identifier.wosWOS:000754551600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGülsoy Toplan, Gizem
dc.language.isoenen_US
dc.publisherTUBITAKen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidant Activityen_US
dc.subjectGC-GC/MSen_US
dc.subjectLC-MS/MSen_US
dc.subjectTeucriumen_US
dc.titlePhytochemical composition and pharmacological activities of Teucrium polium L. Collected from eastern Turkeyen_US
dc.typeArticleen_US

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