Assessment of the Effect of Psoriasis and Methotrexate Treatment on Liver Stiffness by ARFI Imaging

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dc.authoridUnlu, Elif Nisa/0000-0002-4801-8854
dc.authoridKaragun, Ebru/0000-0002-5032-7429
dc.authorwosidGÜÇLÜ, DERYA/GVU-2924-2022
dc.authorwosidUnlu, Elif Nisa/HGD-6227-2022
dc.contributor.authorGuclu, Derya
dc.contributor.authorKaragun, Ebru
dc.contributor.authorUnlu, Elif Nisa
dc.contributor.authorOktay, Mehtap
dc.contributor.authorPasin, Ozge
dc.date.accessioned2024-05-19T14:39:08Z
dc.date.available2024-05-19T14:39:08Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: To investigate whether psoriasis and methotrexate used in its treatment cause liver fibrosis and eventually to evaluate the safety of methotrexate in treatment.Methods: 44 cases were included in the study. Methotrexate-using (group 1, n=14) and methotrexate-not-using (group 2, n=13) psoriasis patients were compared retrospectively with a healthy control group (group 3, n=17) according to mean shear wave rates obtainedResults: Mean shear wave velocities were calculated as 2.57 & PLUSMN; 1.13 m/sec in the patients using methotrexate, 2.31 & PLUSMN; 1.16 m/sec in the patients who did not use methotrexate, and 1.56 & PLUSMN; 0.62 m/sec in the healthy control group. While the average shear wave velocity of the 3rd group was found to be significantly lower than that of the 1st and 2nd groups (p=0.032; p=0.012), no significant difference was observed between the 1st and 2nd groups (p=0.755).Conclusions: Shear wave imaging with ARFI quantification findings revealed no evidence that methotrexate therapy is associated with liver fibrosis in psoriasis patients and we think that the increase in liver tissue stiffness in patients using methotrexate for psoriasis is secondary to the inflammatory process caused by psoriasis itself rather than methotrexate.en_US
dc.identifier.doi10.18521/ktd.1280187
dc.identifier.endpage247en_US
dc.identifier.issn1309-3878
dc.identifier.issue2en_US
dc.identifier.startpage243en_US
dc.identifier.trdizinid1186164en_US
dc.identifier.urihttps://doi.org10.18521/ktd.1280187
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1186164
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4707
dc.identifier.volume15en_US
dc.identifier.wosWOS:001029516200012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectArfien_US
dc.subjectMethotrexateen_US
dc.subjectPsoriasisen_US
dc.subjectShear Wave Elastographyen_US
dc.titleAssessment of the Effect of Psoriasis and Methotrexate Treatment on Liver Stiffness by ARFI Imagingen_US
dc.typeArticleen_US

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