Anticancer potential of albumin bound wnt/beta-catenin pathway inhibitor niclosamide in breast cancer cells
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Albumin-based nanoparticle transport systems (nab-technology) are a new strategy in cancer treatment and we aimed to increase the effectiveness of Niclosamide using this technology. Niclosamide was bound with bovine serum albumin (BSA) by desolvation to yield nanoparticle albumin-bound Niclosamide (nab-Niclo). Nab-Niclo anticancer activity was assessed by proliferation, apoptosis and DNA damage analyses on breast cancer cells. The results implied that nab-Niclo was a more potent agent in the inhibition of cell viability than free Niclosamide and albumin. Flow cytometry analysis show that nab-Niclo triggered apoptosis by caspase and mitochondriadependent pathways in cells and nab-Niclo enhances apoptosis by induce DNA damage in cells. Overall results of this study showed that the nanoparticle form of Niclosamide is effective for breast cancer treatment, presenting a new treatment strategy that can be safe and effective for breast cancer patients.
Açıklama
Anahtar Kelimeler
Albumin, Apoptosis, Breast Cancer, Nanoparticles, Niclosamide
Kaynak
CHEMISTRYSELECT
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
6
Sayı
29
Künye
Ari, F., Erkisa, M., Pekel, G., Erturk, E., Buyukkoroglu, G., Ulukaya, E. (2021). Anticancer Potential of Albumin Bound Wnt/beta-Catenin Pathway Inhibitor Niclosamide in Breast Cancer Cells. Chemistryselect, 6(29), 7463-7475.
