PD-L1 expression correlation with metabolic parameters of 18F-FDG PET/CT in nonsmall cell lung cancer

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dc.contributor.authorAkgun, E.
dc.contributor.authorAkyel, R.
dc.contributor.authorKoc, A. S.
dc.contributor.authorDemirkol, B.
dc.contributor.authorKabalak, P. A.
dc.contributor.authorOzmen, O.
dc.contributor.authorBaydili, K. N.
dc.date.accessioned2024-05-19T14:41:28Z
dc.date.available2024-05-19T14:41:28Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective. - The aim of this study is to evaluate correlation between Programmed cell death ligand 1 (PD -L1) mutation status with metabolic parameters derived from 18-F Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) in treatment naive non -small cell lung cancer (NSCLC). Material -methods. - PD -L1 mutation status was assessed by using the 22C3 DAKO (Group I; n:56), SP263 VENTANA (Group II; n:77) pharm kit in treatment naive NSCLC patients. Metabolic parameters, including volumetric ones of primary lesion (P), lymph node (LN) and distant metastases (M) obtained from FDG PET images. In order to standardize Standardized uptake values (SUVs) measured from images made on different PET/CT devices, SUVs were proportioned to liver(L) SUVs. Results. - In Group I, LN/L SUVmax/mean/peak and M/L SUVmean were significantly higher in cases with strongly positive PD -L1 mutation. In Group II, P/L SUVpeak and P TLG were significantly higher in cases with strongly positive PD -L1 mutation, while LN MTV mutation was higher in weakly positive cases. When all cases are evaluated together, P/L SUVmax/mean/peak, LN/L SUVmax/mean were significantly higher in strongly positive cases. On the other hand, M MTV was found to be higher in mutation -negative cases. Conclusion. - FDG PET can be used as complementary to molecular tests. It should be kept in mind that cases with primary lesions and lymph nodes with high SUVs may be PD -L1 mutant positive. In addition, MTV secondary to possible necrotic content in metastatic lymph nodes and distant organ lesions may be higher in PD -L1 mutation weak positive and negative cases. ?C 2023 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.mednuc.2023.09.008
dc.identifier.endpage32en_US
dc.identifier.issn0928-1258
dc.identifier.issn1878-6820
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85176815185en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org10.1016/j.mednuc.2023.09.008
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5114
dc.identifier.volume48en_US
dc.identifier.wosWOS:001168031900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofMedecine Nucleaire-Imagerie Fonctionnelle Et Metaboliqueen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectFdgen_US
dc.subjectImmunotherapyen_US
dc.subjectMtven_US
dc.subjectNsclcen_US
dc.subjectPd-L1en_US
dc.subjectPet/Cten_US
dc.subjectSuven_US
dc.subjectTlgen_US
dc.titlePD-L1 expression correlation with metabolic parameters of 18F-FDG PET/CT in nonsmall cell lung canceren_US
dc.typeArticleen_US

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