Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1 beta levels in patients with schizophrenia spectrum disorder and their siblings

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dc.authoridHandan Noyan / 0000-0003-0060-6291
dc.authorscopusidHandan Noyan / 56209007800
dc.authorwosidHandan Noyan / AAP-8613-2020
dc.contributor.authorNoyan, Handan
dc.contributor.authorErdağ, Ece
dc.contributor.authorTüzün, Erdem
dc.contributor.authorYaylim, Lhan
dc.contributor.authorKüçükhüseyin, Özlem
dc.contributor.authorHakan, Mehmet Tolgahan
dc.contributor.authorGülöksüz, Sinan
dc.contributor.authorRutten, Bart P. F.
dc.contributor.authorSaka, Meram Can
dc.contributor.authorAtbaşoğlu, Cem
dc.contributor.authorAlptekin, Köksal
dc.contributor.authorVan Os, Jim
dc.contributor.authorUçok, Alp
dc.date.accessioned2021-07-07T08:26:36Z
dc.date.available2021-07-07T08:26:36Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: There is evidence suggesting that tryptophan (TRP)-kynurenine (KYN) pathway dysregulation is involved in the pathophysiology of schizophrenia and is regulated by inflammatory cytokines. The study investigate for the first time whether this dysregulation occurs in advanced stages of the disease as a byproduct or emerges as one of the early and inherited manifestations of schizophrenia. Method: Sera of 148 patients with schizophrenia spectrum disorders (SCZ), 139 unaffected siblings (SIB) and 210 controls were investigated. Serum interleukin (IL)-1 beta levels were measured by ELISA, and TRP, KYN and kynurenic acid (KYNA) levels were measured by a high-performance liquid chromatography system. Also, we collected clinical data by applying Comprehensive Assessment of Symptoms and History in SCZ, and SIS-R in SIB and control groups. Results: Compared to controls, SCZ and SIB groups had lower TRP and higher KYNA levels. TRP levels showed significant differences only between SCZ and controls (p < 0.01). KYNA levels of both SCZ (p <_ 0.001) and SIB (p < 0.05) were higher than controls. No statistical significance was found for KYN levels across groups. SCZ and SIB groups had higher serum IL-1 beta levels than controls (p <_ 0.001). Conclusions: Patients with SCZ and their siblings exhibited similar clinical features and TRP metabolite levels suggesting that TRP-KYN dysregulation may be an inherited component of the disease putatively conferring increased risk to schizophrenia. Elevation of IL-1 beta is one of the factors promoting overconsumption of the TRP-KYN pathway leading to increased production of neuroregulatory KYNA and presumably to neurodegeneration. (c) 2021 Elsevier B.V. All rights reserved.en_US
dc.identifier.citationNoyan, H., Erdağ, E., Tüzün, E., Yaylım, İ., Küçükhüseyin, Ö., Hakan, M. T., ... & Üçok, A. (2021). Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1β levels in patients with schizophrenia spectrum disorder and their siblings. Schizophrenia Research, 229, 27-37.en_US
dc.identifier.doi10.1016/j.schres.2021.01.014en_US
dc.identifier.endpage37en_US
dc.identifier.issn0920-9964en_US
dc.identifier.issn1573-2509en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.1016/j.schres.2021.01.014
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1896
dc.identifier.volume229en_US
dc.identifier.wosWOS:000664029200006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorNoyan, Handan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Başka Kurum Yazarıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokineen_US
dc.subjectInflammationen_US
dc.subjectKynurenineen_US
dc.subjectLiquid Chromatographyen_US
dc.subjectSchizophreniaen_US
dc.subjectTryptophanen_US
dc.titleAssociation of the kynurenine pathway metabolites with clinical, cognitive features and IL-1 beta levels in patients with schizophrenia spectrum disorder and their siblingsen_US
dc.typeArticleen_US

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