Preparation of tetracycline hydrochloride loaded chitosan/silk fibroin/ZnO antibacterial biocomposite hydrogel sponges for wound healing application

Basit Öğe Kaydı
dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridBurçin İzbudak / 0000-0002-5572-7966en_US
dc.authoridBetül Giray / 0000-0001-5099-4881
dc.authorscopusidAyça Bal Öztürk / 57062000100en_US
dc.authorscopusidBurçin İzbudak / 57221779519en_US
dc.authorscopusidBetül Giray / 55531442700
dc.authorwosidAyça Bal Öztürk / M-4472-2018en_US
dc.authorwosidBurçin İzbudak / GXP-7807-2022en_US
dc.authorwosidBetül Giray / AGJ-4156-2022
dc.contributor.authorGiray, Betül
dc.contributor.authorKaptan, Yasemin
dc.contributor.authorKaral Yılmaz, Okşan
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorYılmaz, Bengi
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2023-02-03T05:30:26Z
dc.date.available2023-02-03T05:30:26Z
dc.date.issued2023en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractThree-dimensional (3D) porous biocomposite hydrogel sponges consisting of chitosan (CS), silk fibroin (SF) and ZnO nanoparticles (ZnO NPs) were prepared by the freeze-drying method. The biocomposite was also loaded with tetracycline hydrochloride (TCH) and its wound healing efficacy was investigated in an attempt to enhance healing through the release of the drug. The chemical nature, composition, thermal properties and morphology of the sponges were revealed by FTIR, TGA, and SEM/EDX, analysis. The hydrogels presented the swelling degree in the range of 650-1180% at pH 7.4; 1300-3160% at pH 5.5 and 550-920% at pH 9.0, respectively. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay demonstrated the cytocompatibility of CS/SF/ZnO hydrogels against Wharton's jelly mesenchymal stem cells (WJ-MSCs). CS/SF/ZnO-0 and CS/SF/ZnO-0.5 hydrogels exhibited no cytotoxic effect. In addition, CS/SF/ZnO hydrogels exhibited antimicrobial activity against some tested gram-positive and gram-negative bacteria. Physical immobilization of TCH in hydrogel matrix resulted in sustained release of the drug for more than 2 days at pH 7.4. The results showed that CS/SF/ ZnO-0.5 hydrogel sponge is safe, convenient and could be effective for wound healing applications.en_US
dc.identifier.citationKaptan, Y., Karal-Yilmaz, O., Izbudak, B., Giray, B., Yilmaz, B., & Bal-Ozturk, A. (2023). Preparation of tetracycline hydrochloride loaded chitosan/silk fibroin/ZnO antibacterial biocomposite hydrogel sponges for wound healing application. Journal of Polymer Research, 30(2), 49.en_US
dc.identifier.doi10.1007/s10965-022-03435-2en_US
dc.identifier.issn1022-9760en_US
dc.identifier.issn1572-8935en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85146362170en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s10965-022-03435-2
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3852
dc.identifier.volume30en_US
dc.identifier.wosWOS:000909694100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBal Öztürk, Ayça
dc.institutionauthorİzbudak, Burçin
dc.institutionauthorGiray, Betül
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Polymer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial Wound Dressingen_US
dc.subjectBiocomposite Hydrogel Spongeen_US
dc.subjectSilk Fibroinen_US
dc.subjectChitosanen_US
dc.subjectZno Nanoparticlesen_US
dc.subjectTetracycline Hydrochlorideen_US
dc.subjectDrug Releaseen_US
dc.titlePreparation of tetracycline hydrochloride loaded chitosan/silk fibroin/ZnO antibacterial biocomposite hydrogel sponges for wound healing applicationen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Kaptan-2023-Preparation-of-tetracycline-hydroch.pdf
Boyut:
4.61 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu