Synthesis, characterization, anticancer and antioxidant activity of new nickel(II) and copper(II) flavonoid complexes

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidMerve Erkısa Genel / AAM-1001-2020
dc.contributor.authorAlper, Pınar
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorGençkal, Hasene Mutlu
dc.contributor.authorŞahin, Saliha
dc.contributor.authorUlukaya, Engin
dc.contributor.authorArı, Ferda
dc.date.accessioned2020-08-30T20:06:27Z
dc.date.available2020-08-30T20:06:27Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Rektörlüken_US
dc.description.abstractFlavonoids are natural products which are known to have biological activity for human health. In this study, new mixed ligand complexes of Ni(II) and Cu(II) were synthesized by using flavonoid (quercetin or naringenin) and heterocyclic imine (2,2':6',2 ''-terpyridine or 2,2'-bipyiridine) ligands. The new complexes are [Ni(narH-1)(terpy)Cl]center dot 4H(2)O (1, nar = naringenin, terpy = 2,2':6',2 ''-terpyridine), [Cu(narH-1)(terpy)Cl]center dot H2O (2), and [Cu(queH-1)(bpy)(O3N)]center dot 1.5H(2)O (3, que = quercetin, bpy = 2,2'-bipyiridine). The structural features of the synthesized mixed ligand complexes were investigated using elemental analysis, thermogravimetric analysis, Fourier transform infrared spectroscopy, magnetic susceptibility and molar conductivity measurements. The resulting data demonstrated an octahedral geometry for Complex 1 and Complex 2 and square pyramidal geometry for Complex 3. Antioxidant capacity and total phenolic content of Complexes 1-3 were measured by the Folin-Ciocalteu and ABTS methods. Anti- proliferative effect of complexes were tested by SRB and ATP assays on MCF-7 (breast cancer), A549 (nonsmall cell lung cancer), PC-3 (prostate cancer) and HeLa (human cervical cancer) cell lines. Apoptosis was identified using by the fluorescence imaging, caspase cleaved cytokeratin-18 and flow cytometry analysis. Complex 2 and 3 had high total phenolic content and antioxidant activity. Complex 2 was found to show selective cytotoxicity through the induction of apoptosis on MCF-7 cells with having a very low IC50 value (<0.8 mu M; the half maximum inhibitory concentration) while its ligands showed much higher cytotoxicity (IC50 > 50 mu M). In conclusion, Complex 2 is a highly promising and novel compound for breast cancer and warrants further animal experiments. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipResearch Fund of Bursa Uludag University [OUAP (F)-2014/27]en_US
dc.description.sponsorshipWe thank the Research Fund of Bursa Uludag University for the financial support given to the research Project (Project Number OUAP (F)-2014/27).en_US
dc.identifier.citationAlper, P., Erkisa, M., Genckal, H. M., Sahin, S., Ulukaya, E., & Ari, F. (2019). Synthesis, characterization, anticancer and antioxidant activity of new nickel(II) and copper(II) flavonoid complexes. JOURNAL OF MOLECULAR STRUCTURE, 1196, 783–792. https://doi.org/10.1016/j.molstruc.2019.07.009en_US
dc.identifier.doi10.1016/j.molstruc.2019.07.009en_US
dc.identifier.endpage792en_US
dc.identifier.issn0022-2860en_US
dc.identifier.issn1872-8014en_US
dc.identifier.scopus2-s2.0-85068520445en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage783en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2019.07.009
dc.identifier.urihttps://hdl.handle.net/20.500.12713/520
dc.identifier.volume1196en_US
dc.identifier.wosWOS:000487930600079en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorErkısa Genel, Merveen_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNi(Ii) And Cu(Ii) Flavonoid Complexesen_US
dc.subjectCytotoxicityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectCancer Cellsen_US
dc.titleSynthesis, characterization, anticancer and antioxidant activity of new nickel(II) and copper(II) flavonoid complexesen_US
dc.typeArticleen_US

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