The methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats

Küçük Resim Yok

Tarih

2023

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Background: Teucrium polium and Micromeria fruticosa subspecies are known to be used in traditional medicine for diabetes treatment. Objective: The present study aimed to examine the potential antidiabetic effects and the mechanisms of antidiabetic actions of Teucrium polium L. methanolic extract (TP) and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis methanolic extract (MF) on rats with type 2 diabetes mellitus (DM). Methods: Streptozotocin (STZ) and nicotinamide (NA) were injected intraperitoneally to induce type 2 diabetes mellitus (T2DM) in rats. Plant extracts’ antidiabetic mechanisms of action were investigated with biochemical analyses and histopathological analyses performed. Results: TP and MF treatments reduced the blood glucose levels compared to the untreated diabetic rats. TP reduced TNF-? levels in serum, increased insulin levels in serum and pancreas, reduced SGLT-2 levels in kidneys, reduced GLUT-2 levels in the ileum; and MF reduced TNF-? levels, and increased insulin levels in serum and pancreas, increased GLP-1 levels, and reduced GLUT-2 levels in the ileum, and reduced SGLT-2 levels in kidneys. Treatments improved the histopathological results in the pancreas, kidney, and liver. Conclusions: The results presented in this study demonstrated that TP and MF both have potential antidiabetic effects and may be effective in T2DM treatment. © 2023

Açıklama

Anahtar Kelimeler

Antidiabetic, Medicinal Plants, Micromeria Fruticosa (L.) Druce Subsp. Brachycalyx P. H. Davis, Teucrium Polium L., Type 2 Diabetes Mellitus

Kaynak

Obesity Medicine

WoS Q Değeri

Scopus Q Değeri

Q3

Cilt

44

Sayı

Künye