The methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats

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dc.contributor.authorSermet, S.
dc.contributor.authorCam, M.E.
dc.contributor.authorHazar-Yavuz, A.N.
dc.contributor.authorTaskin, T.
dc.contributor.authorKabatas, G.S.
dc.contributor.authorYazir, Y.
dc.contributor.authorKabasakal L.
dc.date.accessioned2024-05-19T14:33:20Z
dc.date.available2024-05-19T14:33:20Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Teucrium polium and Micromeria fruticosa subspecies are known to be used in traditional medicine for diabetes treatment. Objective: The present study aimed to examine the potential antidiabetic effects and the mechanisms of antidiabetic actions of Teucrium polium L. methanolic extract (TP) and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis methanolic extract (MF) on rats with type 2 diabetes mellitus (DM). Methods: Streptozotocin (STZ) and nicotinamide (NA) were injected intraperitoneally to induce type 2 diabetes mellitus (T2DM) in rats. Plant extracts’ antidiabetic mechanisms of action were investigated with biochemical analyses and histopathological analyses performed. Results: TP and MF treatments reduced the blood glucose levels compared to the untreated diabetic rats. TP reduced TNF-? levels in serum, increased insulin levels in serum and pancreas, reduced SGLT-2 levels in kidneys, reduced GLUT-2 levels in the ileum; and MF reduced TNF-? levels, and increased insulin levels in serum and pancreas, increased GLP-1 levels, and reduced GLUT-2 levels in the ileum, and reduced SGLT-2 levels in kidneys. Treatments improved the histopathological results in the pancreas, kidney, and liver. Conclusions: The results presented in this study demonstrated that TP and MF both have potential antidiabetic effects and may be effective in T2DM treatment. © 2023en_US
dc.description.sponsorshipMarmara Üniversitesi: TDK-2021-10091en_US
dc.description.sponsorshipThis work was supported by the research fund of Marmara University . Project Number: TDK-2021-10091 .en_US
dc.identifier.doi10.1016/j.obmed.2023.100517
dc.identifier.issn2451-8476
dc.identifier.scopus2-s2.0-85176929023en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.obmed.2023.100517
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4194
dc.identifier.volume44en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofObesity Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAntidiabeticen_US
dc.subjectMedicinal Plantsen_US
dc.subjectMicromeria Fruticosa (L.) Druce Subsp. Brachycalyx P. H. Davisen_US
dc.subjectTeucrium Polium L.en_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.titleThe methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley ratsen_US
dc.typeArticleen_US

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