The relationship between vitamin C and oxidative status in periodontitis: A case-control study

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dc.authoridGÜNER, ELİF/0000-0003-0575-5587
dc.authorwosidGÜNER, ELİF/X-8829-2018
dc.contributor.authorEmiroglu, Elif
dc.contributor.authorCakir, Tulin
dc.contributor.authorYuksel, Meral
dc.contributor.authorGunes, Fatma Esra
dc.contributor.authorCekici, Ali
dc.contributor.authorKarakoyun, Berna
dc.date.accessioned2024-05-19T14:46:12Z
dc.date.available2024-05-19T14:46:12Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAim: A co-factor for reactions including collagen hydroxylation, vitamin C prevents oxidative damage to DNA and proteins and may be associated with oxidative stress in periodontitis. This study was designed to test the hypothesis that vitamin C is inversely related to oxidative stress markers in individuals with periodontitis.Material and Methods: This study was conducted with 25 individuals with periodontitis and 24 individuals without periodontitis. Vitamin C intake of participants was determined using a valid food frequency questionnaire, and plasma ascorbic acid levels of participants were measured using high-performance liquid chromatography. Total antioxidant status and total oxidant status were measured in serum and saliva samples, and the oxidative stress index was calculated. Lucigenin-enhanced chemiluminescence assays determined superoxide radicals in saliva.Results: Vitamin C intake in patients with periodontitis was found to be lower than in the control group (124.68 mg/d and 176.71 mg/d, p=0.003, respectively). The plasma ascorbic acid levels and total oxidant status (p=0.03,r=-0.42) and superoxide radical levels (p=0.01,r=-0.53) were inversely correlated in patients with periodontitis.Discussion: Dietary vitamin C intake in patients with periodontitis was lower than in healthy individuals; vitamin C intake may be inversely related to oxidative stress which is the underlying cause of periodontitis.en_US
dc.description.sponsorshipMarmara University Research Fund [SAG-C-YLP-120417-0149]en_US
dc.description.sponsorshipThis work was supported by Marmara University Research Fund (SAG-C-YLP-120417-0149) (https://bapko.marmara.edu.tr/).en_US
dc.identifier.doi10.4328/ACAM.21693
dc.identifier.endpage634en_US
dc.identifier.issn2667-663X
dc.identifier.issue7en_US
dc.identifier.startpage630en_US
dc.identifier.urihttps://doi.org10.4328/ACAM.21693
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5467
dc.identifier.volume14en_US
dc.identifier.wosWOS:001036955000013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectPeriodontitisen_US
dc.subjectAntioxidantsen_US
dc.subjectOxidative Stressen_US
dc.subjectVitamin Cen_US
dc.subjectPeriodontal Diseaseen_US
dc.titleThe relationship between vitamin C and oxidative status in periodontitis: A case-control studyen_US
dc.typeArticleen_US

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