Investigation of Zinc on hemorheological parameters in a rat model of diabetes

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dc.contributor.authorPastacı, Özsobacı, N.
dc.contributor.authorKarış, D.
dc.contributor.authorErcan, A.M.
dc.contributor.authorÖzçelik, D.
dc.date.accessioned2024-05-19T14:33:51Z
dc.date.available2024-05-19T14:33:51Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractDiabetes mellitus (DM) is a complex, chronic metabolic disorder characterized by impaired regulation of blood glucose levels. Zinc (Zn) is an essential trace elements that plays a role in various physiological processes within the body, including those related to diabetes. The current study was investigated the effect of Zn supplementation on hemorheological parameters in a rat model of DM. After induction of DM, 32 male Wistar albino rats were divided into four groups: control, Zn, DM, and Zn+DM. Whole blood viscosity (WBV) was determined by using digital cone and plate viscometer and plasma viscosity (PV) was determined by a Coulter Harkness capillary viscometer. The rats in the DM Group showed a decrease in both Zn levels and body weight, as well as an increase in glucose levels when compared to the control group. Diabetic rats supplemented with Zn displayed lower blood glucose levels and higher concentrations of Zn compared to the DM Group. The higher PV and lower hematocrit level were measured in DM Group than control group and lower PV, higher hematocrit level were measured in Zn+DM group than DM Group. The WBV was measured at four different shear rates (57.6–115.2 - 172.8–230.4 s ?1). A statistically significant increase was observed in the DM group compared to the control group. Additionally, a statistically significant decrease was observed in the Zn+DM Group compared to the DM Group at a shear rate of 230.4 s?1. Erythrocyte rigidity index (Tk) and oxygen delivery index (ODI) were computed under conditions of high shear rate. The rats in the DM group exhibited a reduction in ODI and an elevation in Tk in comparison to the control group. Conversely, the diabetic rats supplemented with Zn exhibited decreased Tk and increased ODI compared to the DM Group. Zn supplementation seems to have a potential beneficial effect for protecting adverse affect of diabetes on hemorheogical parameters and for maintaining vascular health. © 2024 Elsevier GmbHen_US
dc.description.sponsorship3987en_US
dc.description.sponsorshipThe present work was supported by the Istanbul University Scientific Research Projects Unit (Project No: 3987).en_US
dc.identifier.doi10.1016/j.jtemb.2024.127450
dc.identifier.issn0946-672X
dc.identifier.scopus2-s2.0-85190723562en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2024.127450
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4352
dc.identifier.volume84en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier GmbHen_US
dc.relation.ispartofJournal of Trace Elements in Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDiabetesen_US
dc.subjectHemorheologyen_US
dc.subjectPlasma Viscosityen_US
dc.subjectWhole Blood Viscosityen_US
dc.subjectZincen_US
dc.titleInvestigation of Zinc on hemorheological parameters in a rat model of diabetesen_US
dc.typeArticleen_US

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