Two-dimensional molybdenum disulfide/polymer-coated bioactive glass scaffolds for tissue engineering: Fabrication, structural, mechanical, bioactivity, and radiation interaction properties

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dc.authoridTekin, Huseyin Ozan/0000-0002-0997-3488
dc.authoridALMisned, Ghada/0000-0001-9072-4480
dc.authorwosidTekin, Huseyin Ozan/J-9611-2016
dc.contributor.authorDeliormanli, Aylin M.
dc.contributor.authorEnsoylu, Mertcan
dc.contributor.authorALMisned, Ghada
dc.contributor.authorTekin, H. O.
dc.date.accessioned2024-05-19T14:45:51Z
dc.date.available2024-05-19T14:45:51Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractMolybdenum disulfide (MoS2)-based nanostructures are widely used in environmental protection and biomedicine owing to their biological, physical, chemical, electrical, and mechanical properties. In this study, polycaprolactone (PCL)- and polylactide-co-glycolide (PLGA)-coated bioactive glass scaffolds containing MoS2 nanoparticles are prepared, and their usability in bone tissue engineering applications is evaluated. Borate bioactive glass scaffolds are fabricated using the replication method and coated with PCL or PLGA solutions (5 wt %) containing MoS2 (0.1, 0.2, 0.5, 1, and 2 wt%) nanoparticles. The structural and mechanical properties of the scaffolds and their bioactivity in simulated body fluids are investigated comprehensively. The ionization-radiation-shielding properties are investigated using Monte Carlo simulations. The results show that the polymer coating layer and presence of MoS2 nanoparticles in the polymer matrix improves the mechanical properties of the scaffolds. The addition of MoS2 nanoparticles to the structure increases the hydroxyapatiteforming ability of bioactive glass-based composites. Additionally, the prepared composite scaffolds exhibit high radiation-shielding ability owing to the presence of MoS2 nanoparticles embedded in the polymer matrix that shields the glass surface. Bioactive glass composite scaffolds containing MoS2 nanoparticles demonstrate promising potential for bone regeneration and radiation-shielding applications.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [119M935]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) , Project no: 119M935.en_US
dc.identifier.doi10.1016/j.ceramint.2023.04.110
dc.identifier.endpage22874en_US
dc.identifier.issn0272-8842
dc.identifier.issn1873-3956
dc.identifier.issue14en_US
dc.identifier.scopus2-s2.0-85152935015en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage22861en_US
dc.identifier.urihttps://doi.org10.1016/j.ceramint.2023.04.110
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5371
dc.identifier.volume49en_US
dc.identifier.wosWOS:001021171100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCeramics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMos2en_US
dc.subjectBioactive Glassen_US
dc.subjectBone Regenerationen_US
dc.subjectTissue Engineeringen_US
dc.subjectRadiation Shieldingen_US
dc.titleTwo-dimensional molybdenum disulfide/polymer-coated bioactive glass scaffolds for tissue engineering: Fabrication, structural, mechanical, bioactivity, and radiation interaction propertiesen_US
dc.typeArticleen_US

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