Obesity as a modifying factor of periodontal therapy outcomes: local and systemic adipocytokines and oxidative stress markers

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dc.authoridAtaoğlu Tamer / 0000-0003-1937-0290en_US
dc.authorscopusidAtaoğlu Tamer / 6505826250en_US
dc.authorwosidAtaoğlu Tamer / AAL-2379-2021en_US
dc.contributor.authorToy, Vesile Elif
dc.contributor.authorAtaoğlu, Tamer
dc.contributor.authorEltaş, Abubekir
dc.contributor.authorOtlu, Hüsniye Gül
dc.contributor.authorKarabulut, Aysun Bay
dc.date.accessioned2023-01-19T08:22:12Z
dc.date.available2023-01-19T08:22:12Z
dc.date.issued2023en_US
dc.departmentİstinye Üniversitesi, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractObjectives: Adipocytokines and oxidative stress (OS) are involved in the pathogenesis of both obesity and periodontitis. The aim of this study was to evaluate periodontal therapy outcomes in terms of serum and gingival crevicular fluid (GCF) levels of adipocytokines and OS markers in obese patients with periodontitis, in order to have an insight into the association between obesity and periodontitis. Materials and methods: A total of 39 patients (20 obese, 19 non-obese) with periodontitis were included in this study. Clinical periodontal parameters were assessed; serum and GCF levels of adipocytokines and OS markers were evaluated by ELISA at baseline and 3 months after non-surgical periodontal therapy. Results: Significant improvements in clinical periodontal parameters were observed in both groups at 3 months (p < 0.01). While serum levels of TNF-?, leptin, and total oxidant status (TOS) in the obese group were higher at baseline (p < 0.01), leptin levels remained higher at 3 months despite a significant decrease (p < 0.01). Although NSPT improved GCF levels of total antioxidant status (TAS) and TOS in both groups, they were significantly different between the groups after therapy (p < 0.05). Conclusions: It seems that leptin, TNF-?, and TOS contribute to systemic inflammatory and oxidative state in patients with obesity. Despite improvements in clinical periodontal parameters, obesity might be a modulating factor in the development and progression of periodontal disease in terms of some adipocytokines and OS markers. Clinical relevance: Since the global burden of both obesity and periodontitis is continuously increasing, the management of these inflammatory diseases has become more important. The current study contributes to our understanding of the role of OS and adipocytokines on the relationship between obesity and periodontitis by response to periodontal treatment. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.en_US
dc.identifier.citationToy, V. E., Ataoglu, T., Eltas, A., Otlu, H. G., & Karabulut, A. B. (2023). Obesity as a modifying factor of periodontal therapy outcomes: local and systemic adipocytokines and oxidative stress markers. Clinical Oral Investigations, 1-11.en_US
dc.identifier.doi10.1007/s00784-022-04854-7en_US
dc.identifier.issn1432-6981en_US
dc.identifier.scopus2-s2.0-85145674647en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1007/s00784-022-04854-7
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3822
dc.identifier.wosWOS:000909185400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAtaoğlu, Tamer
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipocytokineen_US
dc.subjectNon-Surgical Periodontal Therapyen_US
dc.subjectObesityen_US
dc.subjectOxidative Stressen_US
dc.titleObesity as a modifying factor of periodontal therapy outcomes: local and systemic adipocytokines and oxidative stress markersen_US
dc.typeArticleen_US

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