RT-PCR cycle threshold (Ct) values predicting COVID-19 patients' outcome

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Küçük Resim

Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

BAYRAKOL

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Aim: Clinical presentation of COVID-19 ranges from asymptomatic to fatal cases. Therefore, predictability of prognosis gains importance in managing the disease. The aim of this study is to investigate the relation between RT-PCR cycle threshold (Ct) values and the clinical severity of COVID-19 infection. Material and Methods: A retrospective study was conducted among 1224 COVID-19 patients. A scoring system, which is designed by the World Health Organization was used to classify patients by means of their clinical status. Results: The cut-off for Ct value in ROC curves was 21.52 at the point, when the COVID-19 patient clinic is shifting from ambulatory to hospitalized (79.7% sensitivity, 69% specificity). A significant weak positive correlation was found between age and WHO Score (r= .238 p<0.01) and a significant weak negative correlation was found between Ct value and WHO Score (r=-.068 p<0.05) in COVID-19 patients. Discussion: Patients with lower RT-PCR Ct values were more likely to go through the disease more severely due to higher virulence. Reporting of numerical Ct values may help clinicians in terms of prognosis.

Açıklama

Anahtar Kelimeler

PCR, Cycle Threshold, COVID-19, SARS CoV-2

Kaynak

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE

WoS Q Değeri

N/A

Scopus Q Değeri

Cilt

13

Sayı

8

Künye

Ignak, S., Yalcin, D., Cecen, O., Sonkaya, M. M., Uluisik, I. E., Demirel, O. U. (2022). RT-PCR cycle threshold (Ct) values predicting COVID-19 patients' outcome. Annals of Clinical and Analytical Medicine, 13(8), 882-886.